Hydrolytic enzymes in macrophages from leprosy patients in presence of Mycobacterium leprae.

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dc.contributor.authorMarolia, Jen_US
dc.contributor.authorMahadevan, P Ren_US
dc.date.accessioned1984-10-01en_US
dc.date.accessioned2009-05-28T10:09:49Z
dc.date.available1984-10-01en_US
dc.date.available2009-05-28T10:09:49Z
dc.date.issued1984-10-01en_US
dc.description.abstractPresence of Mycobacterium leprae in association with in vitro cultured macrophages, from bacillary negative long term treated lepromatous leprosy patients, induces reduced level of protein and lowering of hydrolytic enzymes like p-glucuronidase, Lysozyme and Lactic dehydrogenase. Alkaline phosphatase, on the other hand is increased. In the macrophages from normal healthy individuals or tuberculoid leprosy patients, presence of M.leprae increases both protein and levels of all the above enzymes. This observation shows that macrophages from lepromatous leprosy patients are unable to manifest in presence of M. leprae, the key enzymes involved in degradation of complex biological entities phagocytosed by the cells.en_US
dc.identifier.citationMarolia J, Mahadevan PR. Hydrolytic enzymes in macrophages from leprosy patients in presence of Mycobacterium leprae. Indian Journal of Leprosy. 1984 Oct-Dec; 56(4): 776-83en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/54939
dc.language.isoengen_US
dc.subject.meshAcid Phosphatase --analysisen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshGlucuronidase --analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrolases --analysisen_US
dc.subject.meshL-Lactate Dehydrogenase --analysisen_US
dc.subject.meshLeprosy --immunologyen_US
dc.subject.meshMacrophages --enzymologyen_US
dc.subject.meshMuramidase --analysisen_US
dc.subject.meshMycobacterium leprae --physiologyen_US
dc.titleHydrolytic enzymes in macrophages from leprosy patients in presence of Mycobacterium leprae.en_US
dc.typeJournal Articleen_US
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