High level of gamma-glutamyltransferase is a possible risk factor for psoriasis: A nationwide population-based cohort study

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dc.contributor.authorOh, JWen_US
dc.contributor.authorHan, KDen_US
dc.contributor.authorDoh, JYen_US
dc.contributor.authorGee, HYen_US
dc.contributor.authorLee, JH.en_US
dc.date.accessioned2025-06-18T11:42:23Z
dc.date.available2025-06-18T11:42:23Z
dc.date.issued2025-02
dc.description.abstractBackground: Gamma-glutamyl transferase (GGT) has been associated with coronary heart disease, diabetes mellitus, and hypertension, but its association with psoriasis has not yet been elucidated. Aims: We conducted this study to determine the association between the risk of psoriasis and the serum GGT. Methods: We conducted a nationwide population-based study. A total of 9,939,350 people met the enrolment criteria. The study population was classified into four groups based on GGT levels and the risk of psoriasis was calculated for each group. Results: The incidence rates of psoriasis per 1,000 person-years were 2.96105 and 3.68577 in the lowest and highest GGT groups, respectively. After adjusting for age, sex, income, diabetes mellitus, hypertension, dyslipidemia, smoking, alcohol intake, exercise, and body mass index, the highest GGT group showed a significantly increased risk of developing psoriasis (hazard ratio: 1.057, 95% confidence interval: 1.044–1.07). This risk of psoriasis was significantly higher among the old age group (hazard ratio: 1.162, 95% confidence interval: 1.128–1.197) and women (hazard ratio: 1.14, 95% confidence interval: 1.117–1.164). Limitations: The limitations of this study included the retrospective design, International Classification of Diseases code- based diagnosis, small hazard ratio, and non-availability of data on covariates. Conclusion: The GGT level was found to be an independent risk factor for developing psoriasis.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Yonsei University College of Medicine, Yeonsero, Seodaemoon-Gu, Republic of Koreaen_US
dc.identifier.affiliationsDepartment of Statistics and Actuarial Science, Soongsil University, Sangdoro, Dongjak-Gu, Republic of Koreaen_US
dc.identifier.affiliationsDepartment of Dermatology, Seoul St. Mary’s Hospital, Banpo-daero, Seocho-gu, Seoul, Republic of Koreaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Yonsei University College of Medicine, Yeonsero, Seodaemoon-Gu, Republic of Koreaen_US
dc.identifier.affiliationsDepartment of Dermatology, Seoul St. Mary’s Hospital, Banpo-daero, Seocho-gu, Seoul, Republic of Koreaen_US
dc.identifier.citationOh JW, Han KD, Doh JY, Gee HY, Lee JH.. High level of gamma-glutamyltransferase is a possible risk factor for psoriasis: A nationwide population-based cohort study. Indian Journal of Dermatology, Venereology and Leprology. 2025 Feb; 91(1): 23-30en_US
dc.identifier.issn0378-6323
dc.identifier.issn0973-3922
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249399
dc.languageenen_US
dc.publisherScientific Scholar on behalf of Indian Association of Dermatologists, Venereologists & Leprologists (IADVL), India.en_US
dc.relation.issuenumber1en_US
dc.relation.volume91en_US
dc.source.urihttps://dx.doi.org/10.25259/IJDVL_42_2023en_US
dc.subjectGamma-glutamyltransferaseen_US
dc.subjectGGTen_US
dc.subjectpsoriasisen_US
dc.subjectrisk factoren_US
dc.subjectcohort studyen_US
dc.titleHigh level of gamma-glutamyltransferase is a possible risk factor for psoriasis: A nationwide population-based cohort studyen_US
dc.typeJournal Articleen_US
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