Molecular biology of ageing.

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dc.contributor.authorKanungo, M Sen_US
dc.contributor.authorGupta, Sen_US
dc.contributor.authorUpadhyay, Ren_US
dc.date.accessioned1997-10-15en_US
dc.date.accessioned2009-05-27T07:39:36Z
dc.date.available1997-10-15en_US
dc.date.available2009-05-27T07:39:36Z
dc.date.issued1997-10-15en_US
dc.description22 references.en_US
dc.description.abstractThe process of deterioration or ageing of functions that occurs in all organisms after the attainment of reproductive ability is the sum total of the decline in activity of various organs. The functions of different organs begin to deteriorate at different times of the life span and at different rates. It is believed that different genes are involved in the ageing of different organs. Studies on isoenzyme patterns of enzymes show that the genes responsible for coding of different subunits of the enzymes are sequentially expressed during the life span. Also, the decrease in the levels of enzymes seen after adulthood is reversible and can be raised to adult level by inducing their genes by steroid hormones. Another factor that contributes to the decrease in the levels of enzymes is increasing compaction of the chromatin that houses the genes as seen from digestion of chromatin by DNase I and MNase. This decreases the rate of transcription of genes. The expression of many genes declines after adulthood which is due to the decrease in trans-acting nuclear proteins that bind to specific cis-acting sequences in the promoter regions of genes. These proteins are inducible by steroid hormones. Hence the deterioration of functions that occurs after adulthood can be delayed, and the adulthood period can by prolonged by manipulation of the expression of genes.en_US
dc.description.affiliationDepartment of Zoology, Banaras Hindu University, Varanasi.en_US
dc.identifier.citationKanungo MS, Gupta S, Upadhyay R. Molecular biology of ageing. Indian Journal of Medical Research. 1997 Oct; 106(): 413-22en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/21574
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAging --geneticsen_US
dc.subject.meshChromatin --geneticsen_US
dc.subject.meshEnzymes --metabolismen_US
dc.subject.meshGene Expression Regulation, Developmental --physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMiddle Ageden_US
dc.titleMolecular biology of ageing.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeReviewen_US
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