Role of 30 kDa antigen of enteric bacterial pathogens as a possible arthritogenic factor in post-dysenteric reactive arthritis.
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Date
2013-07
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Abstract
Background: Reactive arthritis (ReA)/Reiter’s syndrome (RS) may be caused
as a sequel of infections caused by enteric bacterial pathogens, although the
mechanisms through, which different pathogens cause similar disease are not
clear. Aim: This study was done to look for the presence and role of any common
bacterial antigen among the pathogens isolated from such patients. Materials
and Methods: A total of 51 patients of ReA and 75 controls (three groups of
25 subjects each: Group 1: Patients who did not develop arthritic complications
within 3 months after bacillary dysentery/diarrhea; Group 2: Patients with
other arthritic diseases and Group 3: Normal healthy subjects) were included.
The isolated enteric pathogens were tested to detect the immunodominant
antigens. Results and Conclusions: A common 30 kDa antigen was found
to be specifi cally present among seven arthritogenic enteric bacterial strains
belonging to three genera, Salmonella, Shigella and Hafnia. Post-dysenteric ReA
patients’ sera show higher levels of immunoglobulin G, immunoglobulin M and
immunoglobulin A antibodies against this antigen as compared to the controls.
Lymphocytes of ReA patients recognize this antigen, proliferate and produce
interleukin-2 in response to this antigen more than the lymphocytes of controls.
30 kDa antigen may be a common arthritogenic factor associated with postdysenteric
ReA/RS. The association of Hafnia alvei with post-dysenteric ReA is
described for the fi rst time. Four cases of mycobacterial ReA had an association
with this antigen, suggesting that the arthritogenic antigen of mycobacteria and
enteric bacteria may be of a similar nature.
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Keywords
Enteric infections, post-dysenteric arthritis, reactive arthritis
Citation
Singh Malkit, Ganguli N K, Singh Harminder, Deodhar S D, Sethi Sunil, Sharma Meera. Role of 30 kDa antigen of enteric bacterial pathogens as a possible arthritogenic factor in post-dysenteric reactive arthritis. Indian Journal of Pathology & Microbiology. 2013 Jul-Sept 56 (3): 231-237.