Comparative evaluation of megadose methylprednisolone with dexamethasone for treatment of primary typical optic neuritis.

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dc.contributor.authorMenon, Vimalaen_US
dc.contributor.authorMehrotra, Abhasen_US
dc.contributor.authorSaxena, Rohiten_US
dc.contributor.authorJaffery, Nargis Fen_US
dc.date.accessioned2007-09-19en_US
dc.date.accessioned2009-05-29T07:38:35Z
dc.date.available2007-09-19en_US
dc.date.available2009-05-29T07:38:35Z
dc.date.issued2007-09-19en_US
dc.description.abstractAIM: To compare the efficacy of intravenous methylprednisolone and intravenous dexamethasone on visual recovery and evaluate their side-effects for the treatment of optic neuritis. MATERIALS AND METHODS: Prospective, randomized case-controlled study including 21 patients of acute optic neuritis presenting within eight days of onset and with visual acuity less then 20/60 in the affected eye who were randomly divided into two groups. Group I received intravenous dexamethasone 200 mg once daily for three days and Group II received intravenous methylprednisolone 250 mg/six-hourly for three days followed by oral prednisolone for 11 days. Parameters tested were pupillary reactions, visual acuity, fundus findings, color vision, contrast sensitivity, Goldmann visual fields and biochemical investigations for all patients at presentation and follow-up. RESULTS: Both groups were age and sex-matched. LOGMAR visual acuity at presentation was 1.10 +/- 0.52 in Group I and 1.52 +/- 0.43 in Group II. On day 90 of steroid therapy, visual acuity improved to 0.28 +/- 0.33 in Group I and 0.36 +/- 0.41 in Group II ( P =0.59). At three months there was no statistically significant difference in the color vision, contrast sensitivity, stereoacuity, Goldman fields and the amplitude and latency of visually evoked response between the two groups. The concentration of vitamin C, glucose, sodium, potassium, urea and creatinine were within the reported normal limits. CONCLUSION: Intravenous dexamethasone is an effective treatment for optic neuritis. However, larger studies are required to establish it as a safe, inexpensive and effective modality for the treatment of optic neuritis.en_US
dc.description.affiliationDr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.en_US
dc.identifier.citationMenon V, Mehrotra A, Saxena R, Jaffery NF. Comparative evaluation of megadose methylprednisolone with dexamethasone for treatment of primary typical optic neuritis. Indian Journal of Ophthalmology. 2007 Sep-Oct; 55(5): 355-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/69579
dc.language.isoengen_US
dc.source.urihttps://www.ijo.inen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636008/en_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChilden_US
dc.subject.meshColor Perception --physiologyen_US
dc.subject.meshDexamethasone --administration & dosageen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGlucocorticoids --administration & dosageen_US
dc.subject.meshHumansen_US
dc.subject.meshInjections, Intravenousen_US
dc.subject.meshMaleen_US
dc.subject.meshMethylprednisolone --administration & dosageen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeuroprotective Agents --administration & dosageen_US
dc.subject.meshOphthalmoscopyen_US
dc.subject.meshOptic Neuritis --drug therapyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRecovery of Functionen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshVision, Binocular --physiologyen_US
dc.subject.meshVisual Acuity --physiologyen_US
dc.titleComparative evaluation of megadose methylprednisolone with dexamethasone for treatment of primary typical optic neuritis.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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