An experimental evaluation of anticonvulsant activity of Vitex-negundo.

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dc.contributor.authorTandon, V Ren_US
dc.contributor.authorGupta, R Ken_US
dc.date.accessioned2005-04-21en_US
dc.date.accessioned2009-06-01T05:07:10Z
dc.date.available2005-04-21en_US
dc.date.available2009-06-01T05:07:10Z
dc.date.issued2005-04-21en_US
dc.description.abstractMaximal electroshock seizures (MES) in albino rats and pentylenetetarazole (PTZ) induced seizures in albino mice were used to study anticonvulsant activity of Vitex-negundo leaf extract. The ethanolic leaf extract of Vitex-negundo was administered orally in graded doses (250, 500 and 1000 mg/kg p.o) in both the experimental models and the effects were compared with diphenylhydantoin in MES method and valporic acid in PTZ induced seizures method as standard control respectively. The Vitex-negundo in the doses (250, 500 and 1000 mg/kg, p.o) did not show protection against MES to any significant extent but significant post-ictal depression was observed in the dose of 1000 mg/kg body weight in comparison to control. However, sub-protective dose of test drug (100 mg/ kg, p.o) potentiated the anticonvulsant action of diphenylhydantoin. The test drug in the dose (1000 mg/kg, po) showed 50% protection in clonic seizures and 24-hour mortality against PTZ induced seizures. It also decreased number and duration of convulsions significantly. Vitex-negundo potentiated anticonvulsant activity of valporic acid. The anticonvulsant activity of Vitex-negundo has not been found equi-effective with standard drugs. These findings suggest that Vitex-negundo possesses anticonvulsant activity particularly against PTZ induced convulsions. Moreover, the potentiation of diphenylhydantoin and valporic acid by Vitex-negundo indicates that it may be useful as an adjuvant therapy along with standard anticonvulsants and can possibly lower the requirement of diphenylhydantoin and valporic acid.en_US
dc.description.affiliationPost Graduate Department of Pharmacology & Therapeutics, Govt. Medical College, Jammu 180 001. dr_vishaltandon@yahoo.comen_US
dc.identifier.citationTandon VR, Gupta RK. An experimental evaluation of anticonvulsant activity of Vitex-negundo. Indian Journal of Physiology and Pharmacology. 2005 Apr; 49(2): 199-205en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106366
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnticonvulsants --pharmacologyen_US
dc.subject.meshDrug Combinationsen_US
dc.subject.meshDrug Evaluation, Preclinicalen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshElectroshocken_US
dc.subject.meshMaleen_US
dc.subject.meshPentylenetetrazoleen_US
dc.subject.meshPhenytoin --pharmacologyen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshPlant Leavesen_US
dc.subject.meshPlants, Medicinalen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshReference Standardsen_US
dc.subject.meshSeizures --chemically induceden_US
dc.subject.meshValproic Acid --pharmacologyen_US
dc.subject.meshVitexen_US
dc.titleAn experimental evaluation of anticonvulsant activity of Vitex-negundo.en_US
dc.typeComparative Studyen_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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