Search for newer antileprosy drugs.

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dc.contributor.authorDhople, A Men_US
dc.date.accessioned2000-01-10en_US
dc.date.accessioned2009-05-28T10:15:52Z
dc.date.available2000-01-10en_US
dc.date.available2009-05-28T10:15:52Z
dc.date.issued2000-01-10en_US
dc.description.abstractIn 1991 World Health Organization proclaimed the goal of global elimination of leprosy as a public health problem by year 2000 by implementing multidrug therapy (MDT). Since then the prevalence rate has declined by 85%. However, during the same period the incidence rate of leprosy has remained constant or even has been increasing. This suggests that it will take a long time for the eradication of leprosy and that without in-vitro cultivation of M. leprae, eradication of leprosy is not likely to be achieved. While in-vitro cultivation is a long-term goal, as an immediate measure, there is an urgent need for the development of newer drugs and newer multidrug therapy regimens. Using the in-vitro system for screening potential antileprosy drugs and also using the mouse foot-pad system we have evaluated several compounds in four classes of drugs--dihydrofolate reductase inhibitors, fluoroquinolones, rifampicin analogues and phenazines--and identified at least two compounds that appear to be more potent than dapsone, rifampicin and clofazimine. Newer combinations of rifampicin analogues and fluoroquinolones have also been identified that seem to be better than the combination of rifampicin and ofloxacin.en_US
dc.description.affiliationDepartment of Biological Sciences, Florida Institute of Technology, Melbourne 32901, USA.en_US
dc.identifier.citationDhople AM. Search for newer antileprosy drugs. Indian Journal of Leprosy. 2000 Jan-Mar; 72(1): 5-20en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/55081
dc.language.isoengen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Infective Agents --pharmacologyen_US
dc.subject.meshFluoroquinolonesen_US
dc.subject.meshFolic Acid Antagonists --pharmacologyen_US
dc.subject.meshFoot --microbiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLeprostatic Agents --pharmacologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred BALB Cen_US
dc.subject.meshMicrobial Sensitivity Tests --methodsen_US
dc.subject.meshMycobacterium leprae --drug effectsen_US
dc.subject.meshPhenazines --pharmacologyen_US
dc.subject.meshRifampin --analogs & derivativesen_US
dc.subject.meshTetrahydrofolate Dehydrogenase --metabolismen_US
dc.titleSearch for newer antileprosy drugs.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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