Cyclosporine in steroid dependent and resistant childhood nephrotic syndrome.

Simple item page
dc.contributor.authorIyengar, Arpanaen_US
dc.contributor.authorKarthik, Srilekhaen_US
dc.contributor.authorKumar, Anilen_US
dc.contributor.authorBiswas, Sharmishthaen_US
dc.contributor.authorPhadke, Kishoreen_US
dc.date.accessioned2006-01-09en_US
dc.date.accessioned2009-05-27T06:03:31Z
dc.date.available2006-01-09en_US
dc.date.available2009-05-27T06:03:31Z
dc.date.issued2006-01-09en_US
dc.description.abstractOBJECTIVE: To evaluate the efficacy of cyclosporine (CyA) monotherapy in steroid resistant (SRNS) and steroid dependent (SDNS) nephrotic syndrome in children. DESIGN: A retrospective study. SETTING: Tertiary kidney care center for children at Bangalore. METHODS: Forty-one children with SDNS and SRNS with normal renal functions were treated with CyA at a dose of 6 mg/kg/day initially and maintained at 3 to 4 mg/kg/day if remission was sustained. The dosage was adjusted according to the CyA blood levels in non-responders. RESULTS: The median age of patients was 93 months (range 48-936) months. Thirteen children had minimal change disease (MCNS), 10 had mesangial proliferative glomerulonephritis (GN). Ten had membrano-proliferative (GN) (MPGN) and 8 had focal segmental glomerulosclerosis (FSGS). Median age at onset of disease and median time for CyA usage from disease onset was 22 months and 16 months respectively. Median duration of CyA therapy was 24 months (range 6-72) months. The data was analyzed to determine significance of variables on the outcome. Median follow up was 71 months (range 20-205) months. Eleven children were CyA resistant. Of the remaining 30 who were CyA responders, 22 (73.33%) were CyA dependent. Seven children developed chronic renal failure (CRF). CONCLUSIONS: The predictors for CyA non-responsiveness were steroid resistance, non MCNS on biopsy and longer duration between onset of nephrotic syndrome and CyA usage, irrespective of the age of onset of the disease. There was a higher incidence of CyA dependence among young responders. Patients with CyA resistance are at high risk for significant infections and CRF.en_US
dc.description.affiliationDepartment of Pediatrics, Childrens Kidney Care Center, St. Johns Medical College Hospital, Bangalore 560 034, India.en_US
dc.identifier.citationIyengar A, Karthik S, Kumar A, Biswas S, Phadke K. Cyclosporine in steroid dependent and resistant childhood nephrotic syndrome. Indian Pediatrics. 2006 Jan; 43(1): 14-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/14694
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCyclosporine --therapeutic useen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Function Testsen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshNephrotic Syndrome --diagnosisen_US
dc.subject.meshProbabilityen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshSteroids --therapeutic useen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleCyclosporine in steroid dependent and resistant childhood nephrotic syndrome.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Pediatrics