Profile and prevalence of aspirin resistance in Indian patients with coronary artery disease.

Simple item page
dc.contributor.authorSadiq, P Aen_US
dc.contributor.authorPuri, Aniketen_US
dc.contributor.authorDixit, Madhuen_US
dc.contributor.authorGhatak, Aen_US
dc.contributor.authorDwivedi, Sudhanshu Ken_US
dc.contributor.authorNarain, Varun Sen_US
dc.contributor.authorSaran, Ram Ken_US
dc.contributor.authorPuri, Vijay Ken_US
dc.date.accessioned2005-11-09en_US
dc.date.accessioned2009-05-27T04:21:06Z
dc.date.available2005-11-09en_US
dc.date.available2009-05-27T04:21:06Z
dc.date.issued2005-11-09en_US
dc.description.abstractBACKGROUND: Aspirin resistance is considered to be an enigma and the data available on aspirin resistance is scarce. This study was initiated to prospectively evaluate the prevalence of aspirin resistance in patients with stable coronary artery disease by using an established method of optical platelet aggregation. METHODS AND RESULTS: We studied 50 patients who were on 150 mg of aspirin for the previous 7 days. Fasting blood samples were assessed using optical platelet aggregation (Chronolog Corp, USA). The mean platelet aggregation with 10 microm of adenosine diphosphate in our patient group was 49.42 +/- 23.29% and with 0.5 mg/ ml of arachidonic acid it was 13.58 +/- 21.40%. Aspirin resistance was defined as a mean aggregation of > or =70% with 10 microm of adenosine diphosphate and a mean aggregation of > or =20% with 0.5 mg/ml of arachidonic acid. Aspirin semi responders were defined as those meeting only one of the criteria. Based on these criteria, 2.08% patients were found to be aspirin-resistant, 39.58% were aspirin semi responders and 58.33% were aspirin responders. Females tended to be more aspirin semi responsive (p = 0.08). All other parameters tested, namely, age, smoking, diabetes mellitus, hypertension, obesity, lipids, hemoglobin, platelet count, ejection fraction and drug intake did not show any statistically significant difference among the groups. Thus, in our group 41.66% patients showed inadequate response to aspirin. Conclusions: This study shows that aspirin resistance and aspirin semi responsiveness do occur in the Indian patients and there are no reliable clinical predictors for this condition. The diagnosis therefore relies primarily on laboratory tests.en_US
dc.description.affiliationDepartment of Cardiology, King George Medical University, Lucknow.en_US
dc.identifier.citationSadiq PA, Puri A, Dixit M, Ghatak A, Dwivedi SK, Narain VS, Saran RK, Puri VK. Profile and prevalence of aspirin resistance in Indian patients with coronary artery disease. Indian Heart Journal. 2005 Nov-Dec; 57(6): 658-61en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/3930
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAge Distributionen_US
dc.subject.meshAgeden_US
dc.subject.meshAspirin --adverse effectsen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshCoronary Disease --diagnosisen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrevalenceen_US
dc.subject.meshProbabilityen_US
dc.subject.meshPrognosisen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshSex Distributionen_US
dc.titleProfile and prevalence of aspirin resistance in Indian patients with coronary artery disease.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Heart Journal