Low CD8+ T lymphocyte response to P. falciparum circumsporozoite protein in naturally-exposed malaria endemic populations in Thailand.

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dc.contributor.authorKhusmith, Sen_US
dc.contributor.authorTangteerawatana, Pen_US
dc.contributor.authorLooareesuwan, Sen_US
dc.date.accessioned2009-05-27T14:54:02Z
dc.date.available2009-05-27T14:54:02Z
dc.date.issued1999-09-25en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractCytotoxic T lymphocytes (CTLs) specific for epitope(s) within the circumsporozoite (CS) protein of malaria sporozoite have been shown to play an important role in protective immunity against malaria. Human CTLs against the potential epitope at the carboxy terminal region of CS protein of Plasmodium falciparum 7G8 strain (Pf7G8CS 368-390) were determined in thirty-six falciparum malaria patients and ten healthy controls. Four of 36 individuals and none of the healthy controls developed Pf7G8CS 368-390 specific CTL activity. The CTL activity was antigen specific and CD8+ T cell dependent. Although low CTL response has been determined, the study suggested that there was a correlation between initial parasitemia and the specific Pf7G8CS 368-390 CTL activity. A correlation between such CTL activity and anti-R32tet32 antibody levels among individuals with previous malaria experience was found, which was in contrast to those among individuals with recent malaria infection. All these 4 CTL positive individuals had at least two episodes of clinical malaria experience while all 25 individuals who were exposed to malaria for the first time did not have such a specific CTL response. These results showed that individuals with a history of natural endemic exposure to P. falciparum sporozoite developed low specific CTL responses to Pf7G8CS 368-390, so that previous but recent sporozoite exposure might be a prerequisite for generation of such CS protein specific CTL response.en_US
dc.description.affiliationDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationKhusmith S, Tangteerawatana P, Looareesuwan S. Low CD8+ T lymphocyte response to P. falciparum circumsporozoite protein in naturally-exposed malaria endemic populations in Thailand. The Southeast Asian Journal of Tropical Medicine and Public Health. 1999 Sep; 30(3): 405-11en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/31386
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/1999-30-3/1999-30-3-405.pdfen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, Protozoan --immunologyen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshEpitopesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMalaria, Falciparum --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPeptides --chemistryen_US
dc.subject.meshPlasmodium falciparum --immunologyen_US
dc.subject.meshProtozoan Proteins --immunologyen_US
dc.subject.meshT-Lymphocytes, Cytotoxic --immunologyen_US
dc.subject.meshThailand --epidemiologyen_US
dc.titleLow CD8+ T lymphocyte response to P. falciparum circumsporozoite protein in naturally-exposed malaria endemic populations in Thailand.en_US
dc.typeJournal Articleen_US
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