Thyroid dysfunction in major psychiatric disorders in a hospital based sample.

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dc.contributor.authorRadhakrishnan, Rajiv
dc.contributor.authorCalvin, Sam
dc.contributor.authorSingh, Jyotin Kshitiz
dc.contributor.authorThomas, Binston
dc.contributor.authorSrinivasan, Krishnamachari
dc.date.accessioned2015-01-13T10:52:47Z
dc.date.available2015-01-13T10:52:47Z
dc.date.issued2013-12
dc.description.abstractBackground & objectives: Abnormalities in thyroid hormonal status is common in major psychiatric disorders. Although the relevance of thyroid dysfunction to bipolar disorder is well-recognized, yet the association between thyroid dysfunction and schizophrenia-spectrum disorders is under-emphasized. The aim of this study was to examine and compare the rates of abnormal thyroid hormonal status in patients with schizophrenia-spectrum disorders and mood disorders in an inpatient tertiary care general hospital psychiatry unit. Methods: This was a retrospective hospital-based study on 468 inpatient samples. Data on serum thyroid stimulating hormone (TSH), T3 (triiodothyroxine), T4 (L-thyroxine), free unbound fractions of T3 and T4 (FT3 and FT4) were obtained from records of 343 patients, 18 patients were anti-TPO (anti thyroid peroxidase antibody) positive. The rates of abnormal thyroid hormonal status were compared using the chi square test. Results: Abnormal thyroid hormonal status in general, and presence of hypothyroidism and hyperthyroidism, in particular were seen in 29.3, 25.17 and 4.08 per cent patients with schizophrenia spectrum disorders, respectively. These were comparable to the rates in patients with mood disorders (23.24, 21.62 and 1.62%, respectively). Eleven of the 18 patients with antiTPO positivity had a schizophrenia-spectrum disorder. There were no gender differences. Interpretation & conclusions: Thyroid dysfunction was present in patients with schizophrenia-spectrum disorder as well as mood disorders. Autoimmune thyroid disease was more commonly seen in patients with schizophrenia-spectrum disorders compared to mood disorders. The findings reiterate the relevance of screening patients with schizophrenia-spectrum disorders for abnormal thyroid hormonal status.en_US
dc.identifier.citationRadhakrishnan Rajiv, Calvin Sam, Singh Jyotin Kshitiz, Thomas Binston, Srinivasan Krishnamachari. Thyroid dysfunction in major psychiatric disorders in a hospital based sample. Indian Journal of Medical Research. 2013 Dec; 138(6): 888-893.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/155094
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978977/en_US
dc.subjectAutoimmune thyroiditisen_US
dc.subjecthyperthyroidismen_US
dc.subjecthypothyroidismen_US
dc.subjectmood disorderen_US
dc.subjectschizophreniaen_US
dc.titleThyroid dysfunction in major psychiatric disorders in a hospital based sample.en_US
dc.typeArticleen_US
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