Expression of Human Epidermal Growth Factor Receptor (HER2/neu) and Proliferative Marker Ki-67 in Nonneoplastic, Preneoplastic, Neoplastic Lesions of Gallbladder and Its Association with Clinicopathological Parameters

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dc.contributor.authorYadav, Kiranen_US
dc.contributor.authorArora, Deeptien_US
dc.contributor.authorAwasthi, Seemaen_US
dc.contributor.authorChaudhary, Nikhilen_US
dc.date.accessioned2025-06-18T10:12:00Z
dc.date.available2025-06-18T10:12:00Z
dc.date.issued2025-04
dc.description.abstractIntroduction: Globally, gallbladder carcinoma (GBC) ranks sixth among gastrointestinal tract tumors. Gallbladder cancer is difficult to diagnose. Nevertheless, there is a rising trend of gallbladder cancer; even then, chronic cholecystitis persists commonly among gallbladder lesions nursing various epithelial alterations, ultimately resulting in carcinoma. The current research is performed to evaluate the expression of HER2/neu (human epidermal growth factor receptor 2), Ki?67 in nonneoplastic, preneoplastic, neoplastic gallbladder lesions and to assess the association of expression of HER2/neu, Ki?67 with clinicopathological parameters in gallbladder lesions. Materials and Methods: A total of 76 cases were included in the study, out of which 19 cases were considered under neoplastic group (malignant as well as preneoplastic) and 57 cases (nonneoplastic) were considered under control group. Immunohistochemical staining results of HER2/neu and Ki?67 were evaluated. The correlation was noted among both groups. Statistical analysis was assessed utilizing MS Excel 2021 and SPSS V 25.0 software. The Chi?square test was utilized for evaluating association among variables. P <0.05 was considered statistically significant. A case–control hospital?based study was conducted from March 2022 to July 2024 (For 2 years). The ethical clearance was obtained with IEC number TMU/ IEC/2024?25/007/12. Results: Positive HER2/neu expression (+2, +3) was noted in 26.3% (5/19) of malignant cases (neoplastic group), whereas the expression was completely absent in the nonneoplastic group (P < 0.05). Ki?67 labeling index (?20%) expression was noted in 57.8% (11/19) of the neoplastic group (P < 0.05), while it was completely absent in the nonneoplastic group. Conclusions: HER2/neu and Ki?67 were overexpressed in neoplastic cases as compared with the control group. Moreover, HER2/neu can act as potential target therapeutic modality in GBC cases.en_US
dc.identifier.affiliationsPost Graduate, Department of Pathology, Teerthanker Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsProfessor, Department of Pathology, Teerthanker Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsProfessor and Head, Department of Pathology, Teerthanker Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of Pathology, Teerthanker Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, Indiaen_US
dc.identifier.citationYadav Kiran, Arora Deepti, Awasthi Seema, Chaudhary Nikhil. Expression of Human Epidermal Growth Factor Receptor (HER2/neu) and Proliferative Marker Ki-67 in Nonneoplastic, Preneoplastic, Neoplastic Lesions of Gallbladder and Its Association with Clinicopathological Parameters. Acta Medica International. 2025 Apr; 12(1): 23-26en_US
dc.identifier.issn2349-0578
dc.identifier.issn2349-0896
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247997
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.4103/amit.amit_151_24en_US
dc.subjectCholecystitisen_US
dc.subjectgallbladder carcinomaen_US
dc.subjectHER2 neuen_US
dc.titleExpression of Human Epidermal Growth Factor Receptor (HER2/neu) and Proliferative Marker Ki-67 in Nonneoplastic, Preneoplastic, Neoplastic Lesions of Gallbladder and Its Association with Clinicopathological Parametersen_US
dc.typeJournal Articleen_US
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