Fulminant hepatitis, possible virus origin: a report of seventeen cases in southern Thailand.

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dc.contributor.authorMitarnun, Wen_US
dc.date.accessioned2009-05-27T22:00:28Z
dc.date.available2009-05-27T22:00:28Z
dc.date.issued1990-12-01en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractThis report described seventeen patients suffering from fulminant hepatitis and had a rapid fatal course. They were all residents of Southern Thailand. Fourteen cases were recognized between April and August which is the beginning of the rainy season in this part of the country. All age groups were found with males slightly predominant. Clinical manifestation presented with fever and later developed jaundice, convulsion and other central nervous system symptoms, liver failure and acute renal failure. Four cases had pneumonia and another three cases had pleural effusion. Laboratory investigations revealed hyperbilirubinemia, marked increase in serum transaminases, a variable alkaline phosphatase level and electrolytes derangement. HBsAg was positive in only two of fourteen cases. Blood cultures and serological examination for infections were unfruitful. Histopathological changes of the liver were classified into three types; type 1 massive hepatocellular coagulation necrosis; type 2 massive scattered hepatocellular necrosis and type 3 massive bridging hepatocellular necrosis. Electron microscopy of five cases revealed spherical viral-like particles ranging in size 70 to 90 nm in diameter, in the cytoplasm of liver cells. This is believed to be a unique type of fulminant hepatitis, possibly viral in origin, and were clinically and pathologically different from the previously described fulminant viral hepatitis.en_US
dc.description.affiliationDepartment of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.en_US
dc.identifier.citationMitarnun W. Fulminant hepatitis, possible virus origin: a report of seventeen cases in southern Thailand. Journal of the Medical Association of Thailand. 1990 Dec; 73(12): 674-83en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/45784
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis --microbiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver --ultrastructureen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNecrosisen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshViruses --ultrastructureen_US
dc.titleFulminant hepatitis, possible virus origin: a report of seventeen cases in southern Thailand.en_US
dc.typeJournal Articleen_US
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