Vaginal & rectal carriage of Streptococcus agalactiae in the Czech Republic: incidence, serotypes distribution & susceptibility to antibiotics.

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dc.contributor.authorMotlová, Jen_US
dc.contributor.authorStraková, Len_US
dc.contributor.authorUrbásková, Pen_US
dc.contributor.authorSak, Pen_US
dc.contributor.authorSever, Ten_US
dc.date.accessioned2004-05-03en_US
dc.date.accessioned2009-05-27T07:34:30Z
dc.date.available2004-05-03en_US
dc.date.available2009-05-27T07:34:30Z
dc.date.issued2004-05-03en_US
dc.description.abstractBACKGROUND & OBJECTIVES: Streptococcus agalactiae (group B streptococcus, GBS) is the predominant bacterial agent responsible for invasive perinatal infection. To obtain reliable data on vaginal and rectal carriage of S. agalactiae in pregnant women in Czech Republic, and to formulate a prevention programme of neonatal GBS disease for the Czech Republic, women at childbirth were screened for vaginal and anorectal carriage of GBS. The isolates were serotyped and tested for susceptibility to antimicrobials including those recommended for intrapartum prophylaxis. METHODS: A total of 586 women at childbirth were screened for GBS carriage in vaginal and anorectal regions using the non-enrichment and selective culture media. The isolates were serotyped by precipitation with antisera raised against various serotypes and antigenic extracts prepared according to Lancefield's modification. Mueller Hinton agar with 5 per cent defibrinated sheep blood was used for antimicrobial susceptibility testing. MIC values were evaluated according to the NCCLS criteria. RESULTS: Using selective media, GBS was detected in 172 (29.3%) of 586 women screened, vaginal and anorectal colonization was found in 21.7 and 24.4 per cent of them, respectively, concomitant vaginal and anorectal colonization was recorded in 16.5 per cent of the women studied. Serotypes III (33.2%), Ia (22.0%) and V (13.9%) prevailed among 172 isolates tested. All isolates were susceptible to penicillin, ampicillin and cefotaxime. The rates of GBS resistance to tetracycline, erythromycin and clindamycin were 83.9, 3.8 and 3.2 per cent, respectively. INTERPRETATION & CONCLUSION: GBS carriage in pregnant women in the Czech Republic is rather high as compared with that reported in literature. The most frequent serotypes III, Ia and V, identified in GBS-colonized pregnant women in the Czech Republic, were among those predominant in the USA and Western Europe. Our findings confirm uniform susceptibility of GBS isolates from pregnant women to penicillin and other beta-lactam antibiotics tested. Resistance to erythromycin remains low in the Czech Republic.en_US
dc.description.affiliationNational Reference Laboratory for Streptococci & Enterococci, National Institute of Public Health, Prague, Department of Gynecology, Hospitals of Czech Republic. jmotlova@szu.czen_US
dc.identifier.citationMotlová J, Straková L, Urbásková P, Sak P, Sever T. Vaginal & rectal carriage of Streptococcus agalactiae in the Czech Republic: incidence, serotypes distribution & susceptibility to antibiotics. Indian Journal of Medical Research. 2004 May; 119 Suppl(): 84-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/21245
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnti-Bacterial Agents --pharmacologyen_US
dc.subject.meshCzech Republicen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshRectum --microbiologyen_US
dc.subject.meshStreptococcus agalactiae --classificationen_US
dc.subject.meshVagina --microbiologyen_US
dc.titleVaginal & rectal carriage of Streptococcus agalactiae in the Czech Republic: incidence, serotypes distribution & susceptibility to antibiotics.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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