Evaluation of consistency between local and imported seafood allergen extracts.

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dc.contributor.authorVisitsunthorn, Nualanongen_US
dc.contributor.authorTiranathanakul, Apiradeeen_US
dc.contributor.authorNetrakul, Raweeen_US
dc.contributor.authorVichyanond, Pakiten_US
dc.date.accessioned2009-05-27T18:52:13Z
dc.date.available2009-05-27T18:52:13Z
dc.date.issued2002-08-31en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractBACKGROUND: Seafood is a common cause of food allergy in Thai adults and children. Skin prick test is a safe and convenient way to screen seafood allergy. To date, the Allergy Unit, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University uses imported extracts for seafood skin prick test. The extracts are expensive and may not be the same species as seafood in Thailand. OBJECTIVES: To compare the consistency between local seafood allergen extracts prepared by the Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University and imported seafood allergen extracts. METHODS: The study was a prospective comparative trial performed in children who attended the Pediatric Allergy Clinic, Siriraj Hospital from March 1999 to October 2000. The skin prick test was performed with the local seafood allergen extracts prepared by a pharmacist from the Department of Pharmacology and the imported seafood allergen extracts included shrimp, fish and crab. Histamine and normal saline were used as positive and negative control respectively. The positive result was recorded when wheal reaction was > or = 3 mm larger than negative control. RESULTS: Eighty eight patients (57 boys and 31 girls) were included in this study. The average age was 7.7 years (1-15 years). Half of the patients had a history of seafood allergy. The study showed probable consistency between imported and local skin prick test of shrimp and crab extracts (kappa = 5-7) but no consistency between imported and local skin prick test of fish extracts (kappa < 5). The study also showed no consistency between history of seafood and skin prick test result. CONCLUSION: Local seafood allergen extracts from the Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University are safe but they cannot replace the imported seafood allergen extracts. Further investigations about sensitivity and specificity of both kinds of allergen extracts are necessary.en_US
dc.description.affiliationDepartment of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationVisitsunthorn N, Tiranathanakul A, Netrakul R, Vichyanond P. Evaluation of consistency between local and imported seafood allergen extracts. Journal of the Medical Association of Thailand. 2002 Aug; 85 Suppl 2(): S593-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/40014
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAllergens --adverse effectsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshFood Hypersensitivity --diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPatch Testsen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSampling Studiesen_US
dc.subject.meshSeafood --adverse effectsen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshThailanden_US
dc.titleEvaluation of consistency between local and imported seafood allergen extracts.en_US
dc.typeComparative Studyen_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
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