Ameliorative potential of Aframomum melegueta extract in cadmium-induced hepatic damage and oxidative stress in male Wistar rats.

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dc.contributor.authorOyinloye, Babatunji Emmanuel
dc.contributor.authorAjiboye, Basiru Olaitan
dc.contributor.authorOjo, Oluwafemi Adeleke
dc.contributor.authorMusa, Habiba M
dc.contributor.authorOnikanni, Sunday Amos
dc.contributor.authorOjo, Abiodun Ayodele
dc.date.accessioned2016-09-15T10:36:36Z
dc.date.available2016-09-15T10:36:36Z
dc.date.issued2016-07
dc.description.abstractThe present study was undertaken to explore the ameliorative potential of aqueous extract of Aframomum melegueta (AM) on cadmium-induced hepatic damage in rats. Toxicity was induced by daily administration of 200 mg/L cadmium: Cd (Cd as CdCl2) in the animals’ main drinking water for 21 days. Lipid peroxidation (LPO), catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities were determined in the liver while total protein, albumin, direct bilirubin and total bilirubin concentration as well as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were monitored in the serum and histological examination was carried out. Exposure to cadmium resulted in various alterations in all the evaluated parameters. Treatment with AM (200 or 400 mg/kg bw) extract showed a significant (P <0.05) reversal effect that mitigated the deleterious effect of cadmium. Results of the histological examination also support the above findings. The results suggest that aqueous extracts of A. melegueta when administered orally, could ameliorate cadmium-associated oxidative stress in male Wistar rats in a dose dependant manner via its free radical-scavenging mechanism which could be linked to the synergetic effects between the bioactive constituents present in the extract.en_US
dc.identifier.citationOyinloye Babatunji Emmanuel, Ajiboye Basiru Olaitan, Ojo Oluwafemi Adeleke, Musa Habiba M, Onikanni Sunday Amos, Ojo Abiodun Ayodele. Ameliorative potential of Aframomum melegueta extract in cadmium-induced hepatic damage and oxidative stress in male Wistar rats. Journal of Applied Pharmaceutical Science. 2016 July; 6(7): 94-99.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/177226
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/abstract.php?article_id=1925en_US
dc.subjectAframomum meleguetaen_US
dc.subjectAntioxidanten_US
dc.subjectaqueous extracten_US
dc.subjectcadmium toxicityen_US
dc.subjecthepatoprotectiveen_US
dc.titleAmeliorative potential of Aframomum melegueta extract in cadmium-induced hepatic damage and oxidative stress in male Wistar rats.en_US
dc.typeArticleen_US
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