Effect of artemether on electrocardiogram in severe falciparum malaria.

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dc.contributor.authorKarbwang, Jen_US
dc.contributor.authorLaothavorn, Pen_US
dc.contributor.authorSukontason, Ken_US
dc.contributor.authorThiha, Ten_US
dc.contributor.authorRimchala, Wen_US
dc.contributor.authorNa-Bangchang, Ken_US
dc.contributor.authorBunnag, Den_US
dc.date.accessioned2009-05-27T15:51:39Z
dc.date.available2009-05-27T15:51:39Z
dc.date.issued1997-09-30en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe effect of intramuscular artemether (intramuscular loading dose of 160 mg, followed by 80 mg daily for another 6 doses), in comparison with that of quinine (intravenous infusion of loading dose of 20 mg/kg, followed by 10 mg/kg q 8 hourly for 7 days), on the electrocardiograph of severe falciparum malaria patients were investigated in 102 Thai patients (92 males, 10 females) admitted to Pra Pokklao Hospital, Chantaburi, southeast of Thailand. Fifty patients (19 with quinine and 31 with artemether) were eligible for ECG analysis. Hypotension was found significantly more common in the quinine group (13 vs 2 cases). Thirteen, 5 and 1 patients with quinine treatment, respectively, had tachycardia, non-specific T-wave change and QTc prolongation. No significant dysrhythmia was found despite high plasma quinine concentrations. Five patients died; their ECGs were not significantly different from those who survived. In the group with intramuscular artemether, 17 cases had tachycardia prior to artemether treatment. QTc prolongation and non-specific T-wave change were found in 2 and 6 cases. One patient had RBBB and second degree AV-block on Day 1, but returned to normal on Day 2. No other dysrhythmia or other significant changes in ECG tracing which would suggest any effect of artemether on cardiovascular system were observed.en_US
dc.description.affiliationClinical Pharmacology Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationKarbwang J, Laothavorn P, Sukontason K, Thiha T, Rimchala W, Na-Bangchang K, Bunnag D. Effect of artemether on electrocardiogram in severe falciparum malaria. The Southeast Asian Journal of Tropical Medicine and Public Health. 1997 Sep; 28(3): 472-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/33841
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntimalarials --adverse effectsen_US
dc.subject.meshArrhythmias, Cardiac --chemically induceden_US
dc.subject.meshArtemisininsen_US
dc.subject.meshElectrocardiography --drug effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypotension --chemically induceden_US
dc.subject.meshInfusions, Intravenousen_US
dc.subject.meshInjections, Intramuscularen_US
dc.subject.meshInjections, Intravenousen_US
dc.subject.meshMalaria, Falciparum --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshQuinine --adverse effectsen_US
dc.subject.meshSesquiterpenes --adverse effectsen_US
dc.titleEffect of artemether on electrocardiogram in severe falciparum malaria.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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