Acute Phase Response and its Effect on Short Term Outcome of Bangladeshi patients after On-Pump Cardiac Surgery

Simple item page
dc.contributor.authorKhan, Omar Sadequeen_US
dc.contributor.authorHoque, Rezwanulen_US
dc.contributor.authorRahman, Md. Mostafizuren_US
dc.contributor.authorMorshed, Jesmeenen_US
dc.contributor.authorSaha, Heemelen_US
dc.contributor.authorImtiaz, Nasifen_US
dc.date.accessioned2023-07-21T11:25:41Z
dc.date.available2023-07-21T11:25:41Z
dc.date.issued2022-04
dc.description.abstractBackground: Throughout any surgical procedure, the immune system is generally activated as a physiological response to the surgical trauma. Cardiopulmonary bypass can trigger the inflammatory response in three ways: direct contact activation of the immune system due to exposer of blood to foreign surfaces, ischaemia-reperfusion injury to vital organs as a result of aortic cross clamping, and splanchnic hypoperfusion. Objective: The aim of the study was to observe the acute phase response variables in Bangladeshi patients and to assess the acute phase response and morbidity of the patients after prolonged bypass surgery.Methods:This cross sectional study was conducted in the Department of Cardiac Surgery, BSMMU from January 2009 to December 2010. Fifty patients were selected for the study and were divided into 2 groups on the basis of cardiopulmonary bypass time. Group I was cardiopulmonary bypass time less than 90 minutes and Group II was more than 90 minutes. Data were stored and analyzed with standard computer software (SPSS-15). P < 0.05 was considered statistically significant.Results:The mean duration of cardiopulmonary bypass (CPB) time (55.76�.8 in group I, 131�.35 in group II; P<0.001) and Aortic cross clamp time (28.48�31 in group I, 83.48�.99 in group II; P<0.001) was higher in group II than group I. Analysis of outcome variables showed that mean postoperative ventilation time was 6.24�20 in group I and 9.16�33 in group II. There was significant difference in the ventilation time between two groups (P<0.001). This study showed that there is a definite relationship of wound infection with the prolonged cardiopulmonary bypass time (P<0.001) and also persistently rising CRP increases the chance of wound infection.Conclusions:We may conclude that prolonged cardiopulmonary bypass time is associated with increased acute phase response and morbidity of Bangladeshi patients.en_US
dc.identifier.affiliationsAssistant Professor, Department of Cardiac Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Email: omar_m32@hotmail.com Orcid ID: 0000-0003387-7116en_US
dc.identifier.affiliationsProfessor, Department of Cardiac Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. O rcid ID: 0000-0003-3261-5782en_US
dc.identifier.affiliationsProfessor and Chairman, Department of Cardiac Surgery, Bangladesh Sheikh Mujib Medical University, Dhaka, Bangladesh. Orcid ID: 0000-0002-4715-3173en_US
dc.identifier.affiliationsMedical Officer, Department of Paediatrics, Bangladesh Sheikh Mujib Medical University, Dhaka, Bangladesh. Email: jesm32@gmail.com, Orcid ID: 0000-00025175-0376en_US
dc.identifier.affiliationsAssistant Professor, Department of Thoracic Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Email: heemelsaha@gmail.com, Orcid ID: 0000-0002-7020-5840en_US
dc.identifier.affiliationsMedical Officer, Department of Anaesthesia, Analgesia and Intensive Care Medicine, Bangabandhu Sheikh Mujib, Medical University.Dhaka, Bangladesh. Email: imtiaznasif@yahoo.com, Orcid ID: 0000-0001-8868-4344en_US
dc.identifier.citationKhan Omar Sadeque, Hoque Rezwanul, Rahman Md. Mostafizur, Morshed Jesmeen, Saha Heemel, Imtiaz Nasif. Acute Phase Response and its Effect on Short Term Outcome of Bangladeshi patients after On-Pump Cardiac Surgery. Annals of International Medical and Dental Research. 2022 Apr; 8(2): 209-218en_US
dc.identifier.issn2395-2822
dc.identifier.issn2395-2814
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219963
dc.languageenen_US
dc.publisherScholars Publisheren_US
dc.relation.issuenumber2en_US
dc.relation.volume8en_US
dc.source.urihttps://doi.org/10.53339/aimdr.2022.8.2.27en_US
dc.subjectAcute phase responseen_US
dc.subjectOn-Pump Cardiac Surgeryen_US
dc.subjectCardiopulmonary bypass.en_US
dc.titleAcute Phase Response and its Effect on Short Term Outcome of Bangladeshi patients after On-Pump Cardiac Surgeryen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
AIMDR2022v8n2p209.pdf
Size:
303.66 KB
Format:
Adobe Portable Document Format
Download
Collections
Annals of International Medical and Dental Research