Postnatal development of alcohol dehydrogenase in liver and intestine of rats exposed to ethanol in utero.

Simple item page
dc.contributor.authorBhalla, Sonalien_US
dc.contributor.authorKaur, Kamaljiten_US
dc.contributor.authorMahmood, Akhtaren_US
dc.contributor.authorMahmood, Safrunen_US
dc.date.accessioned2005-01-17en_US
dc.date.accessioned2009-05-27T08:32:31Z
dc.date.available2005-01-17en_US
dc.date.available2009-05-27T08:32:31Z
dc.date.issued2005-01-17en_US
dc.description.abstractBACKGROUND AND OBJECTIVES: Ethanol exposure during gestation induces marked aberrations in growth and development of offsprings collectively known as foetal alcohol syndrome (FAS);. However, its effects on the postnatal development of alcohol dehydrogenase (ADH) are not adequately investigated. Therefore, ADH activity in liver and intestine of rats exposed to ethanol during gestation was studied in relation to postnatal development. METHODS: Pregnant female rats beginning at day 1 of gestation were fed 1 ml of 30 per cent ethanol daily during the entire gestation period. ADH activity was determined in liver and intestine postnatally at day 4, 8, 14, 20 and 30. DNA and RNA contents and intestinal histology were also examined. RESULTS: During the first two weeks of postnatal life, there was no difference in ADH levels of rat liver and intestine in control and prenatally ethanol exposed pups but ADH levels were significantly reduced at 3-4 wk in ethanol fed group compared to control. A similar decrease in DNA and RNA contents of intestine and changes in tissue morphology were observed in ethanol exposed pups during postnatal development. INTERPRETATION AND CONCLUSION: The findings of our study suggested that prenatal ethanol exposure modified ADH activity in liver and intestine during postnatal development. This could affect ethanol metabolism under these conditions.en_US
dc.description.affiliationDepartment of Biochemistry, Panjab University.en_US
dc.identifier.citationBhalla S, Kaur K, Mahmood A, Mahmood S. Postnatal development of alcohol dehydrogenase in liver and intestine of rats exposed to ethanol in utero. Indian Journal of Medical Research. 2005 Jan; 121(1): 39-45en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/24809
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAging --metabolismen_US
dc.subject.meshAlcohol Dehydrogenase --metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newborn --growth & developmenten_US
dc.subject.meshEthanol --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshIntestines --drug effectsen_US
dc.subject.meshLiver --drug effectsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal Exposure Delayed Effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titlePostnatal development of alcohol dehydrogenase in liver and intestine of rats exposed to ethanol in utero.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Medical Research