Evaluation of efficacy and safety of intralesional bleomycin in the treatment of common warts: Results of a pilot study

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dc.contributor.authorMehta, Karan Inder Singhen_US
dc.contributor.authorMahajan, Vikram Ken_US
dc.contributor.authorChauhan, Pushpinder Singhen_US
dc.contributor.authorChauhan, Shailjaen_US
dc.contributor.authorSharma, Vikasen_US
dc.contributor.authorRawat, Rituen_US
dc.date.accessioned2020-01-02T06:52:38Z
dc.date.available2020-01-02T06:52:38Z
dc.date.issued2019-07
dc.description.abstractBackground: This study evaluated the efficacy and safety of intralesional bleomycin in the treatment of common warts in 50 (32 men, 18 women) patients aged between 14 and 80 (mean ± SD, 28.5 ± 13.27) years. Methods: The warts were present over dorsal hands, feet, palms, soles and periungual skin for 1 month to 10 years. They were infiltrated with bleomycin (1 mg/ml) till blanching. The total cumulative dose did not exceed 2 mg in one session. The treatment was repeated after paring of eschar at 2 weeks in case there was no or partial response. The patients were reviewed at 4, 12 and 24 weeks for cure, adverse effects or recurrences and outcome satisfaction levels. Results: Complete cure without recurrence occurred in 40 (80%) patients and partial response occurred in 7 (14%) patients at the end of the 24-week study period. Three patients did not complete follow-up. No major systemic or local adverse effects other than injection site pain for 2–3 days were noted. All cured patients were very satisfied (Likert scale 5). Conclusion: Intralesional bleomycin appears to be an effective and safe treatment for common warts including palmoplantar and periungual warts. It carries the advantage of low dose, no significant adverse effects and high patient satisfaction. Small number of patients, lack of a control group, comparing different bleomycin concentrations and a short follow-up are a few limitations of this study. Better designed studies are warranted for this useful treatment modality.en_US
dc.identifier.affiliationsDepartment of Dermatology, Venereology and Leprosy, Dr. R. P. Government Medical College, Kangra, Himachal Pradesh, Indiaen_US
dc.identifier.citationMehta Karan Inder Singh, Mahajan Vikram K, Chauhan Pushpinder Singh, Chauhan Shailja, Sharma Vikas, Rawat Ritu. Evaluation of efficacy and safety of intralesional bleomycin in the treatment of common warts: Results of a pilot study. Indian Journal of Dermatology, Venereology and Leprology. 2019 Jul; 85(4): 397-404en_US
dc.identifier.issn0378-6323
dc.identifier.issn0973-3922
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/192508
dc.languageenen_US
dc.publisherIndian Association of Dermatologists, Venereologists & Leprologistsen_US
dc.relation.issuenumber4en_US
dc.relation.volume85en_US
dc.source.urihttps://dx.doi.org/10.4103/ijdvl.IJDVL_519_17en_US
dc.subjectBleomycinen_US
dc.subjecthuman papilloma virusen_US
dc.subjectverrucaeen_US
dc.subjectwartsen_US
dc.titleEvaluation of efficacy and safety of intralesional bleomycin in the treatment of common warts: Results of a pilot studyen_US
dc.typeJournal Articleen_US
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