A correlation study of arterial stiffness, cardiac autonomic neuropathy and lipid profile in type 2 diabetes mellitus patients

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dc.contributor.authorKar, Men_US
dc.contributor.authorPriyadarsini, Nen_US
dc.contributor.authorBehera, KK.en_US
dc.date.accessioned2023-08-19T04:57:22Z
dc.date.available2023-08-19T04:57:22Z
dc.date.issued2023-03
dc.description.abstractObjectives: Micro and macrovasculopathy are common complications of undertreated or undiagnosed type 2 diabetes mellitus (T2DM) patients. One of the underlying factors of macrovasculopathy is arterial stiffness, which may lead to cardiovascular and cerebrovascular diseases. Understandably, diabetic micro and macrovasculopathy affect vital functions, which may affect the well-being of the individual. However, few studies have attempted to determine arterial stiffness, cardiac autonomic neuropathy (CAN) and lipid profile separately in South Asian population and examined its associations with T2DM. Moreover, there is a need to understand the mechanistic links among cardiovascular risk factors. This forms the basis of the present study. Materials and Methods: T2DM patients of 53–62 years and age- and gender-matched healthy control subjects were recruited in the cross-sectional and observational study (n = 30 each, eight women). Anthropometric measurements, physiological parameters such as resting heart rate, peripheral blood pressure (PBP), central blood pressure (CBP), augmentation index% (AIx%), brachial-ankle pulse wave velocity and lead II ECG for analysis of heart rate variability parameters were recorded after obtaining the consent of the study participants. The lipid profile and fasting blood glucose were also analysed. Results: Peripheral systolic blood pressure was significantly higher (P = 0.05) in T2DM patients. Dyslipidaemia was evident in T2DM patients. Atherogenic index of plasma (AIP) was also significantly higher in T2DM patients. Correlation analysis revealed a positive association between AIx% with PBP and CBP as well as between AIP index and central systolic blood pressure, serum triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C) levels. AIP index was found to be negatively associated with HF (nu). Serum TG, high-density lipoprotein cholesterol (HDL-C) levels and AIP index have emerged as significant independent predictors of T2DM vasculopathy by multiple regression analysis. Conclusion: In the present study, atherogenic dyslipidaemia was observed in T2DM patients in combination with increased serum levels of TG, VLDL-C and decreased serum levels of HDL-C. Moreover, AIP index, a predictor cardiovascular risk, was found to be significantly higher in T2DM patients. Dyslipidaemia was found to be associated with dysregulation of autonomic nervous system in those patients. A positive association between noninvasive, surrogate markers of arterial stiffness with PBP and CBP indicates that enhanced arterial stiffness may elevate systemic arterial pressure. Therefore, early screening of T2DM patients for the estimation of serum lipid profile, arterial stiffness and cardiac autonomic neuropathy may be performed to unravel diabetic vasculopathy.en_US
dc.identifier.affiliationsDepartment of Physiology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Endocrinology, Diabetes and Metabolism, All India Institute of Medical Sciences, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.citationKar M, Priyadarsini N, Behera KK.. A correlation study of arterial stiffness, cardiac autonomic neuropathy and lipid profile in type 2 diabetes mellitus patients. Indian Journal of Physiology and Pharmacology. 2023 Mar; 67(1): 44-49en_US
dc.identifier.issn0019-5499
dc.identifier.issn2582-2799
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223977
dc.languageenen_US
dc.publisherScientific Scholar on behalf of Association of Physiologists and Pharmacologists of Indiaen_US
dc.relation.issuenumber1en_US
dc.relation.volume67en_US
dc.source.urihttps://doi.org/10.25259/IJPP_339_2022en_US
dc.subjectType 2 diabetes mellitusen_US
dc.subjectArterial stiffnessen_US
dc.subjectCardiac autonomic neuropathy (CAN)en_US
dc.subjectHeart rate variabilityen_US
dc.subjectLipid profileen_US
dc.titleA correlation study of arterial stiffness, cardiac autonomic neuropathy and lipid profile in type 2 diabetes mellitus patientsen_US
dc.typeJournal Articleen_US
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