Effect of omeprazole on gastric mucosa and serum levels of amoxicillin in patients with non-ulcer dyspepsia.

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dc.contributor.authorWittayalertpanya, Sen_US
dc.contributor.authorWannachai, Nen_US
dc.contributor.authorThongnopnua, Pen_US
dc.contributor.authorMahachai, Ven_US
dc.date.accessioned2009-05-27T21:25:17Z
dc.date.available2009-05-27T21:25:17Z
dc.date.issued2000-06-10en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractThe aim of this study was to determine the interaction between omeprazole and amoxicillin, being common agents used in the eradication regimen for H. pylori infection. Amoxicillin concentrations in gastric mucosa and serum were quantitatively analysed in 12 patients with non-ulcer dyspepsia following the administration of one week duration of placebo as group I and omeprazole as group II. The study was a blind, cross-over design with a one week wash out period between the two treatment groups. Six antral gastric mucosa were biopsied 90 minutes after oral administration of amoxicillin. Blood samples were collected before and after administration at intervals up to 6 hours. All samples were analysed for amoxicillin concentration using the HPLC technique. Highly intersubject variations of amoxicillin concentrations were observed. The concentration of amoxicillin in gastric mucosa ranged from 0.00-1.74 and 0.00-1.25 micrograms/mg for group I and group II, respectively, with the mean concentration of 0.25 +/- 0.48 microgram/mg for group I and 0.28 +/- 0.40 microgram/mg for group II. The difference was not statistically significant (p = 0.89). Pharmacokinetic parameters of amoxicillin in serum following regimen I and regimen II were not significantly different (p > 0.05). The mean Cmax values were 14.62 +/- 5.39 and 12.65 +/- 4.76 micrograms/ml, the Tmax were 2.3 +/- 1.0 and 2.0 +/- 0.9 hour and the AUC0-6 were 40.79 +/- 13.26 and 38.75 +/- 15.04 micrograms/ml.h in the group I and group II, respectively. From these results, we concluded that omeprazole has no effect on gastric mucosa level nor serum levels of amoxicillin. The therapeutic efficacy of using these two agents in the eradication regimen of H. pylori may be related to other factors rather than pharmacokinetic interaction.en_US
dc.description.affiliationDepartment of Pharmacology, Faculty of Pharmaceutical Science, Chulalongkorn University, Bangkok, Thailand.en_US
dc.identifier.citationWittayalertpanya S, Wannachai N, Thongnopnua P, Mahachai V. Effect of omeprazole on gastric mucosa and serum levels of amoxicillin in patients with non-ulcer dyspepsia. Journal of the Medical Association of Thailand. 2000 Jun; 83(6): 611-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/44759
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshAmoxicillin --administration & dosageen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshDyspepsia --drug therapyen_US
dc.subject.meshEnzyme Inhibitors --administration & dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastric Mucosa --drug effectsen_US
dc.subject.meshHelicobacter Infections --drug therapyen_US
dc.subject.meshHelicobacter pylori --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOmeprazole --administration & dosageen_US
dc.subject.meshPenicillins --administration & dosageen_US
dc.subject.meshProbabilityen_US
dc.subject.meshReference Valuesen_US
dc.titleEffect of omeprazole on gastric mucosa and serum levels of amoxicillin in patients with non-ulcer dyspepsia.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeControlled Clinical Trialen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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