Effect of Load on In-situ Rat Skeletal Muscle Preparation Under Free Loaded and After Loaded Condition

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dc.contributor.authorSharma, Hanjabam Barunen_US
dc.contributor.authorJeevitha, P.en_US
dc.contributor.authorBade, Geetanjalien_US
dc.contributor.authorKaur, Simranen_US
dc.date.accessioned2020-04-23T07:40:18Z
dc.date.available2020-04-23T07:40:18Z
dc.date.issued2019-01
dc.description.abstractPurpose of the study: The effect of free loaded and after loaded condition in mammalian skeletal musclecontraction can be studied using an in-situ nerve-muscle preparation in rat. The experimental setup mimicsthe physiological conditions very closely unlike the classical in vitro frog nerve-muscle preparation andhence could be considered as an effective practical module to demonstrate the work done in a skeletalmuscle in both free loaded and after loaded condition.Methodology: A simple, feasible and novel practical is designed in which muscle twitch is recorded in anin-situ nerve-muscle preparation of an anaesthetized rat under free loaded and after loaded condition atdifferent weights using an isotonic transducer. Work done was calculated under free loaded and after loadedcondition and compared.Main finding: Difference was observed with respect to displacement and work done during free loaded andafter loaded condition. Work done was higher in free loaded condition.Conclusion: We propose a simple and novel practical to demonstrate the effect of free loaded and afterloaded condition in muscle twitch for undergraduate teaching in physiology.en_US
dc.identifier.affiliationsDepartment of Physiology,All India Institute of Medical Sciences,New DelhIen_US
dc.identifier.citationSharma Hanjabam Barun, Jeevitha P., Bade Geetanjali, Kaur Simran. Effect of Load on In-situ Rat Skeletal Muscle Preparation Under Free Loaded and After Loaded Condition. Indian Journal of Physiology and Pharmacology. 2019 Jan; 1: 73-78en_US
dc.identifier.issn0019-5499
dc.identifier.issn2582 – 2799
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/198920
dc.languageenen_US
dc.publisherScientific Scholaren_US
dc.relation.issuenumber1en_US
dc.relation.volume63en_US
dc.source.urihttps://ijpp.com/IJPP%20archives/2019_63_1/73-78.pdfen_US
dc.titleEffect of Load on In-situ Rat Skeletal Muscle Preparation Under Free Loaded and After Loaded Conditionen_US
dc.typeJournal Articleen_US
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