Experience on loading dose--quinine therapy in cerebral malaria.

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dc.contributor.authorMehta, S Ren_US
dc.contributor.authorLazar, A Ien_US
dc.contributor.authorKasthuri, A Sen_US
dc.date.accessioned1994-05-01en_US
dc.date.accessioned2009-05-30T19:45:42Z
dc.date.available1994-05-01en_US
dc.date.available2009-05-30T19:45:42Z
dc.date.issued1994-05-01en_US
dc.description.abstractTwelve cases of cerebral malaria due to plasmodium falciparum, treated with loading dose of quinine (20 mg/kg salt in 500 ml of 5% glucose infused IV in 4 hrs) are compared with eleven age and sex matched cases treated with conventional dose of 10 mg/kg. The parasite clearance rate was significantly faster in loading dose group. There was no difference in recovery time: the interval between the initiation of treatment to full recovery of consciousness in both groups. One patient had pretreatment hypoglycaemia and two cases in the conventional dose group developed hypoglycaemia during therapy. One patient died in conventional dose group due to multi-organ failure. Two litres blood exchange transfusion was also tried for this case. Mild cinchonism occurred in two cases after loading dose while this was observed only in one case in conventional dose group. There was no significant hypotension or ECG changes in any patient. Loading dose of quinine seems to be well tolerated and may clear parasitaemia faster in case of malaria due to Plasmodium falciparum (PF).en_US
dc.description.affiliationDept of Medicine, Armed Forces Medical College, Pune.en_US
dc.identifier.citationMehta SR, Lazar AI, Kasthuri AS. Experience on loading dose--quinine therapy in cerebral malaria. Journal of the Association of Physicians of India. 1994 May; 42(5): 376-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/87076
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshBlood Glucose --analysisen_US
dc.subject.meshBlood Transfusionen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCause of Deathen_US
dc.subject.meshConsciousnessen_US
dc.subject.meshElectrocardiography --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshInjections, Intravenousen_US
dc.subject.meshMalaria, Cerebral --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMultiple Organ Failureen_US
dc.subject.meshParasitemiaen_US
dc.subject.meshQuinine --administration & dosageen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleExperience on loading dose--quinine therapy in cerebral malaria.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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