Update Ayurveda 2014 Abstracts Poster Presentation.
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2015-05
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UA/PP/01
Antimalarial activity of Caesalpinia crista
Chitralekha L. Mane, S. S. Sant
Sharir Kriya Dept., Government Ayurved College, Nanded, India
Email: dr.chitramane101088@gmail.com
Malaria is one of the most life‑threatening infectious
diseases worldwide and claims the millions of people’s life
each year. The appearance of drug‑resistance Plasmodium
falciparum has made the treatment of malaria increasingly
problematic, and thus, it is a dire need to search the new
alternatives of current drugs. Latakaranja i.e. Caesalpinia
Crista from family Caesalpiniaceae is one of the herbs
mentioned in all Ayurvedic Texts and traditionally used
for periodic fever. The CH2Cl2 extract of the seed
kernels of Caesalpinia crista, which exhibited promising
antimalarial activity against Plasmodium. 44 cassane‑ and
norcassane‑type diterpenes isolated from Caesalpinia
crista evaluated for their antimalarial activity against the
malaria parasite Plasmodium falciparum. Most of the tested
diterpenes displayed antimalarial activity and norcaesalpinin
E showed the most potent activity. The combination of its
roasted seed powder and Pippali 1:1 proportion given with
Honey approximately 0.5 gm thrice a day for three days
duration. Another combination recommended for malaria
is the powders of marich and latakaranj. The splenic
enlargement due to malaria responds well to Latakaranj.
UA/PP/02
Role of Panchakarma in surgical diseases:
A comprehensive approach
Amit Kumar Negi, P.Hemantha Kumar, B. Swapna
National Institute of Ayurveda, Jaipur, India
Email: amitnegiayurveda@gmail.com
Background: On par with surgical techniques used to
uproot the pathology of a disease, Panchakarma, a
major therapeutic contribution of Ayurveda, concedes
ultimate bio‑purificatory methods with radical action in
the management of a disease. In view of their importance,
Acharya Sushruta incorporated Panchakarma procedures in
the management of surgical diseases. Objective: To explore
the Panchakarma procedures those can be practiced safely
in surgical diseases. Materials and Methods: Panchakarma is
indicated in conditions like Gudabhramsha, Yonibhramsha,
Arshas, Bhagandar, Parikartika, Vidradhi, Bhagna, among
Shashti upakramas of vrana etc. Vamanakarma in
Dushtavrana, Virechanakarma in bhagandara, osteomyelitis;
swedana karma in soft tissue injury and post plaster removal
after fracture, Basti (Enema) in patient preparation for
shalya karma, Anuvasanavasti in parikartika, Uttaravasti in
vatashteela, Kativasti and greevavasti in lumbar spondylosis,
cervical spondylosis respectively, Vranavasti in chronic non
healing ulcers and osteomyelitis, are some of the conditions
where panchakarma is indicated. Raktamokshana, performed
in amajavranashopha, thrombosed external haemorrhoids
is considered by Sushruta as one of the panchakarma
procedures. Results: Panchakarma therapy performed
either as main line or as an adjuvant in any surgical disease
eliminates the causative factors completely or alleviate to
the extent that the disease may not need further surgical
intervention, which is conducive enough to the diseased.
Conclusion: In many surgical diseases, Panchakarma
procedures being performed at pre‑operative, operative and
post‑operative levels play important role either as the first
line of treatment or as an adjunct to the main treatment.
UA/PP/03
Development and validation of assessment criteria for
Agni – inferences from a pilot study
Ashwathykutty.V, Pawankumar Godatwar, Reetu Sharma
Department of Rog Nidan and Vikriti Vijnan, National Institute of
Ayurveda, Jaipur, India
Email: toashwathy@gmail.com
Back ground: The tools which were developed till date to
assess Agni were identifying the Agnibala, not the state
of Agni. These conventional methods which assess the
degree of Agnibala do not offer any help in identifying the
doshas involved in the derangement of Agni. Considering the
lacunae in the current methods, a short questionnaire was
developed to assess the four states of Agni. Objectives: To
develop the questionnaire and validate it in different steps.
Materials and Methods: For framing the questionnaire, the
variables were identified and proper scoring was done.
Validation was done in different phases. Survey study was
conducted in 45 healthy volunteers, aged between 20‑40
yrs, of either sex, randomly selected from the NIA campus,
Jaipur. The internal consistencies among the questions were
assessed using the crohnbach’s α using SPSS. Results:
Totally 45 volunteers were analysed. 26 individuals were
found to have samagni, 13 were with mandagni, 4 were with
vishamagni and 2 were of Tishnagni. In statistical analysis,
it is found that the Crohnbach’sα is. 639 which shows an
acceptable limit of internal consistency. Conclusion: Agni
being the key factor in ayurvedic treatment, it should be
thoroughly understood and assessed before the treatment
is decided. This can help us identifying the most suitable
medicine in its proper dose and dosage form. The study can
throw some light in this regard and can be performed with
further clarifications and advancements.
UA/PP/04
Junk food habit as a risk factor in Grahani dosha: An
epidemiological study
Atul Jain, Nadira Khatoon, Sevatkar Balkrishan,
Sisir Kumar Mandal, Pawankumar Godatwar
Update Ayurveda 2014 Abstracts
Poster Presentation
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Abstracts
These abstracts were presented at the Update Ayurveda 2014 at Mumbai, Maharashtra, India. The abstracts were screened
by the scientific committee of Update Ayurveda 2014 and are not peer reviewed by J-AIM. © Update Ayurveda 2014.
27
Department of Roga nidana and Vikriti vijnana, National Institute of
Ayurveda, Jaipur, India
Email: atuljainu@gmail.com
Background: In the recent years, there has been
an unprecedented increase of incidences related to
gastrointestinal system due to changing in life style, diet
pattern, behavioural pattern and mental stress and strain.
One such type of common gastrointestinal disorder is
Grahani Dosha that is a psychosomatic disorder caused
by regular intake of junk food that weakens the digestive
fire and disharmony is produced between the digestion
and absorption of body. Objective: To conduct a Survey
study of junk food as a risk factor in Grahani patients.
Materials and Methods: A survey study of total 250
Volunteers was conducted at NIA OPD, IPD, various camps
in Jaipur, Rajasthan and certain junk food outlets. Volunteers
were screened on the basis of prepared questionnaires.
Results: On survey study, various risk factors that are
considered significant for the selection of Grahani patients
like Junk food user including addicted, Frequent and Regular
60%, Problem after taking junk food 60%, Heart burn 38.8%,
Delayed digestion of food 54%, Fatigued/Lethargic 45.2%,
Gurgling sound in abdomen 52.8%, Tendency of flatulence
34.4%, Altered bowel habit 29.2%, Disrupted agni 44%,
altered Jarana sakti 39.2% and altered Abhyavarana sakti
46% subjects. Conclusion: Maximum prevalence was found
in patients leading sedentary life styles and emotionally
disturbed patients were more prone for the disease. It was
concluded that continuous intake of junk food is risk factor
for Grahani roga rather than sometimes intake of junk food.
UA/PP/05
Concept of Herbal Nebulizer in Ayurveda
Gaurav Soni, J. Manohar, Sandeep Lahange
Department of Sharir Rachana, National Institute of Ayurveda,
Jaipur, India
Email: gauravsonilko@gmail.com
Background: Ayurveda by itself can tackle the needs
of health care today, though some adaptation can be
more valuable in today’s world. Ayurveda has a 3 tier
structure i.e. Tatwa (Principle), Shastra (Theory) and
Vyavahara (Practice). Vyavahara is the development of
new applications according to particular problems that
manifest differently. Medicinal requirement is not always
fulfilled by systemic route so there is need to change the
route to administer the drug. Objective: In Ayurveda proper
Nebulization therapy has been not explained but the process
of Dhumpana and Nasya may be analogous in some extent.
Here in this work we had discussed various facts and factors
for establishing new route of drug administration in form of
herbal nebulizer. Materials and Methods: Literal review of
Ayurvedic Classics and other relevant contemporary science
literature along with Internet material and research papers.
Results: Inhalation as a route for the administration of drug
especially for the management of respiratory disorders is as
old as Ayurveda. Technique of nebulizer in form of aerosol
through Nebulization apparatus for herbal drugs is better
route for respiratory distress. Conclusion: This work only
gives the glimpse of concept of inhalation therapy described
in Ayurvedic classics and establishment of newer concept
of drug administration route i.e. through Nebulization. Yet
a herculean work is needed for better and precise way of
converting herbal drugs in form suitable for inhalation therapy.
UA/PP/06
Role of Yastimadhu Ghruta Tarpan in Computer Vision
Syndrome (CVS)
Kavita Thorat
Dr. DY Patil College of Ayurved and Research Centre, Nerul,
Navi Mumbai, India
Email: drkavitathorat@gmail.com
Background: Eyes are the doors of wisdom; immense
importance has been given to the eyes in our classics. In
this era of computers, radiations these doors are affected
first and fast. So how are we going to face the challenge
of preserving vision? The answer is in the hands of
ayurveda, one of the oldest organized ways of life rather
than just a system of medicine, the vision of ayurvedic
fraternity is to restore vision to entire world. After all its
ayurveda which proclaimed to the entire world about the
preventive aspect for the first time “Swasthasya Swasthya
Rakshanam”. Objectives: To assess the effect of Yastimadhu
Ghruta Tarpan in Computer Vision Syndrome (CVS).
Materials and Methods: Drugs – Yastimadhu Ghruta, Udid
flour. Tarpan procedure was performed according to samhitas.
30 patients were studied. All necessary examinations were
carried out before and after the treatment. All the findings
are recorded on standard proforma specially prepared for
this purpose. Result: Yashtimadhu ghruta tarpan significantly
reduce symptoms of CVS Conclusion: Yashtimadhu ghruta
tarpan reduce symptoms of CVS for longer duration.
UA/PP/07
Hepatoprotective potential of lycopene in paracetamol
induced hepatotoxicity: An experimental study
Manjunatha T A, Joshi SS
Department of Pharmacology and Therapeutics, Seth G S Medical
College and K E M Hospital, Mumbai, India
Email: drmanju186@yahoo.co.in
Background: Lycopene is a carotenoid present in many fruits
and vegetables, predominantly tomato (Solanum lycopersicum),
with proven antioxidant properties. Objective: To evaluate
the hepatoprotective activity of lycopene in paracetamol
induced hepatotoxicity in Wistar rats. Materials and Methods:
Lycopene (10% powder) in doses of 5 mg/kg/day and 10 mg/
kg/day, 0.5% carboxymethylcellulose (vehicle control) and
silymarin 50 mg/kg/day (positive control) were administered
orally for 7 days in Wistar rats, followed by administration
of single oral dose of paracetamol 2 g/kg. Liver function
parameters and morphological features of liver were measured,
and histopathological examination of liver was carried out.
Parametric data in different treatment groups was statistically
analyzed using one way ANOVA (analysis of variance)
with post‑hoc Tukey’s test (P < 0.05). Non parametric
data was analyzed using Kruskal‑Wallis test (P < 0.05).
Results: There was significant increase in serum levels of
bilirubin, and transaminases with decrease in total protein
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Abstracts
These abstracts were presented at the Update Ayurveda 2014 at Mumbai, Maharashtra, India. The abstracts were screened
by the scientific committee of Update Ayurveda 2014 and are not peer reviewed by J-AIM. © Update Ayurveda 2014.
28
level, in the disease control, vehicle control and lycopene
5 mg/kg/day groups, reflecting liver injury with paracetamol.
A significant decrease in serum levels of the markers and
significant increase in total protein was observed in lycopene
10 mg/kg/day and silymarin treated groups, indicating
recovery of hepatic cells. Histopathological examination
of disease control, vehicle control, and lycopene 5 mg/kg/
day groups, showed variable degrees of fatty degeneration
and cellular necrosis whereas lycopene 10 mg/kg/day and
silymarin treated animals revealed normal hepatic architecture
without any cellular necrosis and fatty infiltration. Conclusion:
Lycopene 10 mg/kg/day afforded significant protection against
paracetamol induced hepatotoxicity in Wistar rats.
UA/PP/08
Antibacterial activity of hydro alcoholic extract of
Gymnema sylvestre
Rajesh Kumar Suman, Manjusha Borde, Ipseeta Ray Mohanty,
Vijay Mane, Y A Deshmukh, A D Urekar
MGM Medical College, Kamothe, Navi Mumbai, Iindia
Email: manjusha_dhande@yahoo.co.in
Background: Gymnema sylvestre (Family‑ Asclepiadaceae)
is one of the important medicinal plants of India widely
used in the Indian System of Medicine. The leaves
of Gymnema sylvestre possess anti‑inflammatory,
anti‑ helmenthic, laxative, cardio‑tonic, expectorant
and antipyretic properties. Objective: To evaluate the
antibacterial activity of hydro alcoholic leaves extract of
Gymnema Sylvestre against E. coli, and Acinatobactor.
Material and Methods: The hydroalcoholic extract of
leaves of Gymnema Sylvestre was purchased from Sanat
Pharmaceutical, New Delhi. The extract was tested
against standard strain and clinical isolate of E. coli, and
Acinatobactor at different concentration (1 mg, 2 mg,
4 mg and 8 mg) by Agar well diffusion technique using
Muller Hinton agar. The routine antibiotic Cefotaxime was
used as control drug against test bacteria under similar
condition. Results: The hydro alcoholic leaves extract of
Gymnema Sylvestre at concentration of 1mg, 2 mg, 4 mg
and 8 mg were tested against E. coli and acinatobactor.
Gymnema Sylvestre demonstrated significant zone of
inhibition at different concentration (1mg, 2 mg, 4mg and
8 mg) against E. coli (ATCC 25922) and E. Coli from clinical
isolate (urine) as compared with control drug. The herbal
extract also showed significant antimicrobial activity against
Acinatobactor from clinical isolate (Tracheal Secretion)
as compared with control drug under similar condition.
Conclusion: The herb Gymnema Sylvestre has a significant
antibacterial property against E. coli and Acinatobactor.
UA/PP/09
Indian festivals with the view of Ayurveda
Priti Patil, Baldev Kumar Dhiman
Department of Basic Principles, National Institute of Ayurveda,
Jaipur, India
Email: preets297@gmail.com
Background: The Sanskrit word for festivals is utsava means
removal of worldly sorrows. The condition of human body
depends on the continuous interaction between internal and
external factor. Based on this principle, festival delicacies
and of course, the diet and lifestyle regimen (dinacharya
and ritucharya) of Ayurveda have been adapted to seasonal
changes. Our ancients were well informed about science
behind festivals and also about human tendencies so
they just tried to link up festivals with religious values.
Objectives: (1) To study the actual logic behind celebration of
Indian festivals. (2) To study the linkage of some festival with
seasonal changes. (3) To explore the scientific basis of festivals
apart from religion aspect. Materials and Methods: All the
matters of some commonest festivals are collected from the
books available and from local traditions followed in home.
Ayurvedic dincharya and ritucharya matter is collected from
Ayurvedic samhitas and correlation of gathered matter
was done to discover the purpose of how traditions meet
technology. Result and Conclusion: Various scientific facts
came to knowledge when the study done and scientific basis
behind celebration of festival are explored out. Our ancients
celebrating festivals for avoiding the seasonal diseases
creating havoc in day today’s life. And as they linked festival
with religious values, it becomes easy to continue it for long
time i.e. even up to this generation and definitely this tradition
will be continued for years after year.
UA/PP/10
Bioactive fraction of Couroupita guianensis prevent
AGE formation and protein oxidation against
glucose‑induced protein glycation
Shweta Lotankar, Gauresh Somani, Sadhana Sathaye
Pharmacology Research Laboratory‑II, Department of
Pharmaceutical Sciences and Technology, Institute of Chemical
Technology, Mumbai, India
Email: sslotankar13@gmail.com
Background: Advanced glycation end products are
glycated proteins responsible for the development and
worsening of diabetic complications. Objective: The
present experiment has measured the effect of Couroupita
guianensis (CG) extract and its fraction during the early
stage, middle stage and last stage of AGE formation.
Material and Methods: The methanol extract of Couroupita
guianensis (MCG) was prepared by soxhlet extraction. It was
further extracted with ethyl acetate (EA), butanol and water
to afford three fractions. Glycation inhibitory activity of CG
fraction was determined by using an in vitro glucose‑bovine
serum albumin (BSA) assay. The protein oxidation was
examined using the level of protein carbonyl content and
thiol group. Identification of the bioactive components was
attempted using different analytical techniques such as
HPTLC, HPLC and LC‑MS. Results: When BSA was incubated
with glucose, the significant increase in fluorescence
intensity was observed after 21 days of the experiment.
When MCG and its fraction at different concentrations
were added to reaction mixture containing BSA/Glucose,
the fluorescence intensity was significantly decreased in a
concentration‑dependent manner. Amongst all the fractions
investigated, EACG showed decrease in the fluorescence
intensity at less concentration followed by butanol fraction.
Further, CG fraction also prevented oxidative protein
damages, including effects on protein carbonyl formation
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Abstracts
These abstracts were presented at the Update Ayurveda 2014 at Mumbai, Maharashtra, India. The abstracts were screened
by the scientific committee of Update Ayurveda 2014 and are not peer reviewed by J-AIM. © Update Ayurveda 2014.
29
and thiol oxidation of BSA. Conclusion: EACG could be
used as a preventive measure against glycation‑associated
complications in diabetes.
UA/PP/11
Novel and efficient method for extraction and isolation
of parthenin from Parthenium hysterophorus
Siddeshwar H Pawar, S. R. Kulkarni
Department of Pharmacognosy and Phytochemistry, Bombay
College of Pharmacy, Kalina, Santacruz (E), Mumbai, India
Email: 2008siddeshwarp@gmail.com
Background: Plant Parthenium hysterophorus contains
parthenin which is responsible for various pharmacological
activities such as anticancer, antibacterial, insecticidal
etc. Objective: To make parthenin standard quickly
and easily; there was a need of novel method of
extraction of parthenin from Parthenium hysterophorus
for study of its pharmacological activities on large scale.
Materials and Methods: So current study was focused on
efficient method of extraction and isolation of parthenin and
other allied components from Parthenium hysterophorus.
Various methods have been tried for isolation of parthenin
from Parthenium hysterophorus extract includes; direct
column chromatography of plant extract, solvent
partitioning method, treatment of extract followed by
column chromatography and by non solvent addition
method. This isolated compound was characterized
using M.P., HPTLC, HPLC, UV, IR, NMR and GC‑MS.
Results: Isolated compound was confirmed as parthenin.
Non solvent addition method gave good result on the
basis of time, yield and other expenditure as compared to
other methods. Conclusion: The present study concludes
that Non solvent addition method can be considered as
novel method for extraction of parthenin from Parthenium
hysterophorus
UA/PP/12
A Pilot study, the effect of classical Virechan karma
in the management of Hypertension. Case series.
Ujwala Hivale, Santoshkumar Bhatted
Department of Panchakarma, National Institute of Ayurveda,
Jaipur, India
Email: ujwala.hivale27@gmail.com,
Background: Hypertension one of the grave conditions
causes 6% of death worldwide. About 800 million people
in the world are suffering from hypertension. Various
studies reveal that there is a strong relation between
hypertension and coronary artery disease. Though number
of antihypertensive drugs are available but the complication
of hypertension are frequently observed which life are
threatening. Objective: The present study was done to
assess the effect of complete classical virechana karma
in hypertension. Materials and Methods: Three patients
suffering with hypertension were selected randomly and
classical virechana was given. Results: Moderate reduction
in both systolic and diastolic blood pressure was noted after
the treatment. Conclusion: Classical Virechana treatment is
moderately effective in reducing blood pressure.
UA/PP/13
A conceptual study to explore the scientific basis of
Bhutavidya in the context of Brihattrayi
Deepak Rahangdale, Yogendra Kamble, Baldev Kumar
Department of Basic Principle, National Institute of Ayurveda,
Jaipur, India
Email: deepak23aug87@gmail.com
Ayurveda is the science of life and among the eight paths,
of whose Bhutavidya deals with the mainly imbalance
of mind and its diseases and treatment. To evaluate the
literature related to bhutavidya from brihattrayi and also
to establish the underline cause effect theory of treatment
modalities of bhutavidya with logical reasoning. Collection
and collation of literature of bhuta‑vidya from brihattrayi.
Its development and cause with the purview of sociology
Incorporation of bhutavidya in brihattrayi. Cause effect
relationship accordance with pathology and treatment
establishing current relevancy of the topic and the treatment.
Bhutavidya deals with all sorts of problems that have
no direct physical explanation in terms of dosha, dhatu
or mala and also concerned with diseases of unknown
cause which are designated as idiopathic. Bhutavidya is
not much different from Psychotherapy and Hypnotism
of the modern and along with mind power. Bhutavidya is
somewhat manasa vikara explained in Ayurveda but keen
observation and thinking leads to conclude that bhutavidya
is described under all the categories i.e. nija, agantuja and
manasa. As the dinacarya, ritucarya, sadvritta, along with
pathya‑apathya and vyayama explained in Ayurveda will
help to achieve physical and mental health.
UA/PP/14
Multilevel qualitative LC − MS metabolomic approach
to study the responses of Tinospora cordifolia
treatment in hyperlipidemic patients
Amey Shirolkar1, A Pawase1, C Mulye1, R Dabur2
1Department of Biochemistry, National Research Institute of
Basic Ayurvedic Sciences (NRIBAS‑CCRAS), Kothrud, Pune,
Maharashtra, 2Department of Biochemistry, Maharshi Dayanand
University (MDU), Rohtak, Haryana, India
Email: amey_593@rediffmail.com
Background: Tinospora cordifolia (willd.) miers juice (TCJ)
possesses antihyperlipidemic properties and its mechanism
need to be studied. Objective: A multicompartmental
nontargeted LC − MS metabolomics approach was
used to study the plasma metabolic responses of
hyperlipidemic patients after treatment with TCJ.
Materials and Methods: 20 individuals (8 hyperlipidemic)
underwent TCJ treatment (100ml decoction/individual/day).
Plasma and plasma extracted lipid samples obtained
from healthy, hyperlipidemic (HPL) and TCJ treated
hyperlipidemic (HPL‑PT) individuals were processed and
analyzed in a standardized UPLC‑QTOFMS instrument.
A supervised multivariate data analyses with PCA and
PLS‑DA statistical models were performed for pattern
recognition. The method was validated by analyzing several
known, unknown, abundant and minute metabolites from
experimental categories. Metabolic pathways were drawn
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Abstracts
These abstracts were presented at the Update Ayurveda 2014 at Mumbai, Maharashtra, India. The abstracts were screened
by the scientific committee of Update Ayurveda 2014 and are not peer reviewed by J-AIM. © Update Ayurveda 2014.
30
to understand the molecular mechanism of TCJ action.
Results: PCA and PLS‑DA revealed marked effects of the drug
on plasma metabolites. In plasma positive category carnitine,
N‑methyltryptamine, 7a‑hydroxy‑3‑oxo‑5b‑cholanoic
acid, 7‑Hydroxy‑3‑oxocholanoic acid, cholic acid
glucuronide, lactosylceramide were downregulated in
HPL‑PT; sphinganine, L‑acetylcarnitine, L‑phenylalanine
and proline betaine were upregulated. In plasma
negative category several fatty acid derivatives were
downregulated; guanidoacetic acid and nicotinamide
ribotide were upregulated. In plasma lipid positive group
alhpa‑tocopheronolactone was downregulated; in plasma
lipid negative group propionyl‑CoA, 3‑hydroxybutyryl‑CoA
and angiotensin‑II were down regulated (FC > 2.0).
Conclusions: The LCESI‑QTOFMS/MS method in positive
and negative ion polarity mode helps to qualitatively study
the plasma metabolites post TCJ treatment in HPL without
sample derivatization. The effect of TCJ was observed
across several metabolic pathways. Several unknown
metabolites obtained in this study would assist in finding
newer plasma biomarkers of hyperlipidemia.
UA/PP/15
A comparative clinical study of the Varnya effect of
Kumkumadi Taila and its cream preparations’
Kavita Kumari Jain, Monika Sharma, Rajendra Prasad Sharma
Department of Rasashastra and Bhaishajya Kalpana,
National Institute of Ayurveda, Jaipur, India
Email: 123123kavijain@gmail.com
Background: Cosmetology is a science of beautifying skin
and its appendages. Continuous conscious efforts of man
towards looking beautiful as well as increasing skin problems
caused by changing lifestyle have given birth to cosmetology.
Its concept is present since Vedic times. Cosmetic approach
is seen in Sushruta Samhita also. This is evident from the
22 upkramas explained under the heading of vaikritapaham
as alepana, pariseka, utsadana, etc. Varnya dravya works on
bhrajaka pitta, which is responsible for colour complexion.
varnya dravyas helps in pitta, vata prasadana, ras, rakta
shodhana thus improving varna. Objectives: To explore and
compare clinically the varnya effect of Kumkumadi Taila and
its cream preparations. Materials and Methods: A clinical
study was conducted with 4 groups, containing 15 patients
each. Patients were recruited from OPD of National Institute
of Ayurveda, Jaipur. The following medicines were given
for external application in the 4 groups. Group 1 received
Kumkumadi Tailam, group 2 received varnya cream 1 (cold
cream), group 3 received varnya cream 2 (vanishing cream)
and group 4 received varnya cream 3 (all purpose cream)
Results: It was found that Tailam therapy worked better
than cream therapy. Conclusion: Cold cream worked better
than all purpose cream, which in turn worked better than
vanishing cream. Dark complexioned people got more benefit
than fair complexioned.
UA/PP/16
Evaluation of Ayurvedic herbal formulations
Pranav Shirkar, Neha Thali, Neha Khopkar, S.R. Kulkarni
Department of Pharmacognosy and Phytochemistry, Bombay
College of Pharmacy, Kalina, Santacruz (E), Mumbai, India
Email: shirkarpranav@gmail.com
Background: Ayurvedic herbal solid dosage forms namely pills
and tablets were evaluated for stability of phytochemicals
by HPTLC pattern and safety with respect to microbial
bio‑burden and pesticide residue. Objective: To study the
safety and stability of herbal formulations prepared by
conventional methods. Materials and Methods: The decoction
of mixture of constituent herbs in proportions same as that
of formulated pills and tablets were prepared. Pills were
prepared manually by two methods namely sun drying and
shade drying. The tablets were prepared by conventional wet
granulation method using SLS as disintegrating agent. The
granules were dried at 40°C and machine punched. HPTLC
was performed to evaluate the stability of components in
the formulation. The microbial bio‑burden of formulations
was studied by using Nutrient agar Hi‑media make broth.
Presence of pesticides like dimethoate, glyphosate and
cypermethrin was tested by conventional TLC method. The
mobile phase of dichloromethane: acetone (9:1) and water:
ethanol: acetic acid (3.5:6:0.5) was used for dimethoate
and glyphosate respectively which were visualized by
spraying 0.3% ninhydrin. None of the formulation showed
pesticide residue. Results: Microbial bio‑burden results were
as such, the pills did not show microbial growth whereas
tablets showed 8.4 × 103 CFU/gm. Pesticide residue was
found in none of the formulations. Conclusion: The above
studies helped us in concluding that the herbal formulations
prepared by conventional method are safe for use and have
fairly good stability.
UA/PP/17
Hypoglycaemic activity of Murrayakoenigii
(meethaneem) leaves collected from Udaipur,
Rajasthan
Pratibha Chaturvedi1, Abhay Chowdhary2
1Department of Biochemistry, Haffkine Institute for Training,
Research and Testing, Parel, Mumbai, 2Director, Haffkine Institute for
Training, Research and Testing, Parel, Mumbai, India
Email: pratibha.c@rediffmail.com
Background: Medicinal plants continue to provide
treasured therapeutic agents by the ancient time. In many
forms, plants are being used in the traditional systems
of medicine in many parts of the world, especially in
rural communities for diverse types of ailments. Diabetes
mellitus is one of the utmost common chronic diseases in
the whole world. Many synthetic drugs are used to control
hyperglycaemia induced by Diabetes mellitus. However,
owing to host resistance and other adverse effects of these
compoundsthis becomesessential to find out the natural
resource to fight with hyperglycaemia.In current study,
an approach was made to evaluate the hypoglycaemic
activity of Murrayakoenigii (Meethaneem) leaves
powder. Objective: Evaluation of hypoglycaemic
activity of Murrayakoenigii (Meethaneem) leaves.
Materials and Methods: Male wistar rat was used
as experimental animal. Diabetes was induced by an
intraperitoneal (i.p.) injection of streptozotocin. Animals
with blood glucose >200mg % were selected and used for
the study. Glibenclamide (500μg/kg; standard hypoglcaemic
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Abstracts
These abstracts were presented at the Update Ayurveda 2014 at Mumbai, Maharashtra, India. The abstracts were screened
by the scientific committee of Update Ayurveda 2014 and are not peer reviewed by J-AIM. © Update Ayurveda 2014.
31
agent) and single dose of aqueous slurry of dried leaves powder
of Murrayakoenigii were administered to selected animals.
Blood was examined for its glucose level at 1‑6, 24 hours
separately. Results: Murrayakoenigii (Meethaneem) leaves
slurry exhibited a significant hypoglycaemic activity on fourth
day of dosing, which reduced the glucose level up to 56% that
is more effective than standard drug Glebenclamide (49%).
Conclusion: Murrayakoenigii (Meethaneem) leaves aqueous
slurry has the potentiality to act as hypoglycaemic agent.
UA/PP/18
Advance Technique in Treatment of Planter Fasciitis
[Calcaneal Spur]
Ramesh Rajguru
Dr.Mane Medical Foundation and Research Centre, Rahuri,
Ahmednagar, India
Email: drramesh12rajguru@gmail.com
Background: As mentioned in Ayurvediya Panchkarma
chikitsa, Raktamokshan by using Leeches [Jalouka] is
beneficial in the case of Planter Fasciitis. As Jaloukas are
not easily available in the rural areas and if made available
unable to survive in hot climatic conditions. So an alternate
technique was developed using a 5ml syringe for the suction
of blood. Materials and Methods: 5 ml syringe with cut
from the nosal end and a hole made in the piston for the
support to the syringe in proper direction, blade no 11, spirit,
cotton, gauge, sticking, needles, gloves were used during
the procedure. Patient lied on the examination table for the
procedure. Painful area was located and marked with the
pen. Small cuts known as Prachchan in Ayurveda were done
with the help of blade, till bleeding starts from the superficial
capillaries. Cuts should be up to 1mm deep. The syringe was
applied over the bleeding area and 5ml blood was collected.
Results: Patient felt complete relief after the procedure. Same
procedure can be repeated after 15 days if there is partial
relief. In most of cases there was no need of repetition.
Conclusion: With the help of Raktamokshan by Prachchan
karma, relief is observed in the patients of Planter Fasciitis.
UA/PP/19
Role of Carica Papaya leaf extract on Dengue Fever
and Dengue Haemorrhagic Fever
Jayashree C. Khendkar, J. J. Pawar, S. S. Sant
Department of Sharir Kriya., Government Ayurved College, Nanded, India
Email: jayu914@yahoo.co.in
Dengue fever is a viral disease that caused by viral
serotype Flaviviridae and carried by Aedes aegypti as
the vector. Today dengue fever affects a vast number of
people in over 125 countries and responsible for a number
of deaths. A patient with dengue fever presents typically
with fever, headache and rash known as the dengue triad.
Dengue haemorrhagic fever and typically manifests as
abdominal pain, bleeding, and even circulatory collapse.
Infected patients receive supportive management with
fluids, blood and blood products. There is still no specific
antiviral drug available for the treatment of dengue fever.
In Ayurveda, Erandkarkati i.e. Carica Papaya leaves has
Swedjanan action also its prabhav is Jwaraghna. It is
Raktashodhaka, Katupoushtika and Balya to Hridaya. Carica
papaya from the family Caricaceae is a medicinal plant
whose leaves contain carpinine and carpaine. The PTAFR
gene which is known to be responsible for increased platelet
production and aggregation was expressed 13.42‑folds
among the patients who consumed the papaya leaf juice as
compared to the control group indicating that the juice had
played an important role in arresting bleeding tendencies
among these patients due to its immuno‑modulatory effect.
The administration of CPLJ (Carica papaya Leaf Juice) in
dengue fever and dengue haemorrhagic fever is safe and
does induce the rapid increase in platelet count. It may
play a valuable role in the management of dengue fever in
the near future.
UA/PP/20
Study of correlation of Ama with free radical
Vilas S. Kad, Vrushali V Rane
SVNHT’s Ayurved Mahavidyalaya, Shri Shivajinagar, Rahuri,
Ahemadnagar, Maharashra, India
Email: dr.vrushalirane@yahoo.com
Ama is considered to be one of the important aspects of
development of diseases process in the body. Majority
of endogenous diseases beings with formation of ama.
It has tremendous capacity to vitiate the doshas and
disturbing the homestasis (dhatusamya). Ama is the
resultant of improper digestion or partially digestion of
the food particle due to hypofunction of jatharagni and
also due to accumulation of mala in the body and also
considered as parathamdoshdushti. It may be considered
as partially or incompletely metabolized dhatu in case of
dhatwagnimandya.In modern parameters, ama is supposed
to be deadly free radical. Free radical is an atom/molecule
that contain one or more unpaired electron, which requires
neutralization by free radical scavengers. Ama is not a
single entity but is a generalized term, which can be applied
to many malformed substances in the body. This Ama
is responsible for production of various diseases. In the
same way free radical are also found to be the root cause
of many diseases. Here we discus about properties and
qualities of both entities. Which are similar and dissimilar
and also whether free radical can be considered under Ama.
The present article attempts to correlate the most recent
concept of free radical with that of the concept of Ama
with the help of some diseases like cancer, rheumatoid
arthritis, stroke, mayocardial infraction, diabetes, alzheimer
diseases, cardiovascular diseases, parkinson’s diseases,
atherosclerosis.
UA/PP/21
In‑vitro evaluation of Anti‑oxidant and Anti‑inflammatory
activity of Triphala Churna, Dashmool Kadha, and
Dashmool Bharad market formulations
Tejas V Mistry, Samidha G Joshi, Renuka P Munshi
Dept of Clinical Pharmacology, TNMC and BYL Nair Ch. Hospital,
Mumbai, India
Email: tejas.v.mistry@gmail.com
Background: Triphala and Dashmool are 2 commonly used
anti‑inflammatory polyherbal formulations. Triphala is
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Abstracts
These abstracts were presented at the Update Ayurveda 2014 at Mumbai, Maharashtra, India. The abstracts were screened
by the scientific committee of Update Ayurveda 2014 and are not peer reviewed by J-AIM. © Update Ayurveda 2014.
32
reported to have antioxidant, anti‑inflammatory, antipyretic,
analgesic, antibacterial, antimutagenic, anticancer,
and hypoglycemic effects whi le Dashmool has
anti‑inflammatory properties and is effective in treating
bronchitis, headache, cough, drowsiness, weakness,
impotence, and digestive problems. Objective: The
present study was carried out to evaluate the anti‑oxidant
and anti‑inflammatory activities of Triphala churna,
Dashmool bharad, and Dashmool kadha formulations
using in‑vitro methods. Materials and Methods: Triphala
Churna (manufactured by Shree Dhootpapeshwar),
Dashmool Kadha (manufactured by Sandhu brothers) and
Dashmool Bharad (locally purchased) were used in the
study. DPPH, ABTS and FRAC assays were used to evaluate
the anti‑oxidant properties while Protein denaturation
and HRBC membrane stabilization assays were used
evaluate anti‑inflammatory activities of the formulations.
α‑Tocopherol was used as standard for anti‑oxidant assay
and Diclofenac sodium for anti‑inflammatory assays.
Results: 80μg of Triphala Churna showed 91.47% DPPH
radical scavenging activity while α‑Tocopherol showed
90.23%. 5mg of Dashmool Kadha showed 85.56% while
Dashmool Bharad showed 27.19% DPPH radical scavenging
activity. ABTS and FRAC showed similar results. All three
formulations showed minimal anti‑inflammatory activity in
both the assays used. Conclusions: Triphala and Dashmool
were found to have high antioxidant activity and radical
scavenging activity against various antioxidant systems
in vitro with minimal anti‑inflammatory effect which needs
to be confirmed by other assays.
Description
Keywords
Citation
Update Ayurveda 2014 Abstracts Poster Presentation. Journal of Ayurveda and Integrative Medicine. 2015 May; 6(suppl_5): 26-32.