Basal luteinizing hormone/follicle stimulating hormone ratio in diagnosis of central precocious puberty.

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dc.contributor.authorSupornsilchai, Vichiten_US
dc.contributor.authorHiranrat, Paraveeen_US
dc.contributor.authorWacharasindhu, Suttipongen_US
dc.contributor.authorSrivuthana, Sumarleeen_US
dc.contributor.authorAroonparkmongkol, Suphaben_US
dc.date.accessioned2009-05-27T19:30:56Z
dc.date.available2009-05-27T19:30:56Z
dc.date.issued2003-06-22en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractBACKGROUND: Precocious puberty is characterized by breast development in girls prior to 8 years old and may have acne, adult odor, growth spurt and menstruation. Conventionally, gonadotropin releasing hormone (GnRH) stimulation test is a gold standard for diagnosis of central precocious puberty but it is a time-comsuming procedure that is not practical on an out patient basis. OBJECTIVE: To evaluate the basal luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio in diagnosis of central precocious puberty in order to save time and cost. SUBJECTS AND METHOD: The GnRH stimulation tests were performed on 51 girls with breast development before 8 years old. The 51 girls were divided into 2 groups, 24 girls with central precocious puberty (CPP) and 27 girls with premature thelarche (PT), and the clinical data and GnRH stimulation tests data were compared between the 2 groups. The authors also compared the clinical data and GnRH stimulation tests data between 13 girls with PT and 12 girls with thelarche variants (TV) who developed puberty approximately 1 year later as confirmed by GnRH stimulation test. RESULTS: Girls with CPP had a large bone age and chronological age ratio and advancement of breast staging. Girls with TV had a greater level of basal luteinizing hormone (LH), peak LH and 120 min estradiol than girls with PT. Basal luteinizing hormone and follicle stimulating hormone (FSH) ratio greater than 0.2 can be used to diagnose CPP with 75 per cent sensitivity, 85 per cent specificity, 82 per cent positive predictive value (PPV) and 82 per cent negative predictive value (NPV). CONCLUSION: Girls with CPP have a basal LH/FSH ratio greater than 0.2 and this can be used as a cut-off point for the diagnosis CPP.en_US
dc.description.affiliationEndocrinology Unit, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.en_US
dc.identifier.citationSupornsilchai V, Hiranrat P, Wacharasindhu S, Srivuthana S, Aroonparkmongkol S. Basal luteinizing hormone/follicle stimulating hormone ratio in diagnosis of central precocious puberty. Journal of the Medical Association of Thailand. 2003 Jun; 86 Suppl 2(): S145-51en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/41276
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshFollicle Stimulating Hormone --blooden_US
dc.subject.meshHormones --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshLuteinizing Hormone --blooden_US
dc.subject.meshPredictive Value of Testsen_US
dc.subject.meshPuberty, Precocious --blooden_US
dc.subject.meshReproducibility of Resultsen_US
dc.titleBasal luteinizing hormone/follicle stimulating hormone ratio in diagnosis of central precocious puberty.en_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
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