Risk factors for penicillin-resistant Streptococcus pneumoniae acquisition in patients in Bangkok.

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dc.contributor.authorDejthevapor, Cen_US
dc.contributor.authorVibhagool, Aen_US
dc.contributor.authorThakkinstian, Aen_US
dc.contributor.authorSirinavi, Sen_US
dc.contributor.authorVorachit, Men_US
dc.date.accessioned2009-05-27T15:16:39Z
dc.date.available2009-05-27T15:16:39Z
dc.date.issued2000-12-21en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractTo identify risk factors for acquisition of penicillin-resistant Streptococcus pneumoniae (PRSP) in patients in Bangkok, using a case-control study, the study included patients with clinical specimens which grew S. pneumoniae during January to December 1997, treated at a teaching hospital in Bangkok. Penicillin susceptibility was determined by E-test and strains with MIC of > 0.1 microg/ml were considered resistant. Cases were the patients who had PRSP, and patients who had penicillin-susceptible S. pneumoniae (PSSP) were controls. The study variables included age 15 years or younger, immunocompromised status, ventilatory support, and antibiotic use or hospitalization within the previous 3 months. There were 73 cases and 51 controls. Their ages were 0 to 87 years, with median age of cases 4 and controls 49 years. Pneumonia was the most common type of infection, being 47% in cases and 45% in controls. Univariate analysis revealed significant association of PRSP acquisition with previous antibiotic use (p<0.0001), age < or = 15 years (p=0.001) and previous hospitalization (p=0.002). Logistic regression analysis in order to adjust for confounding effects showed that the only significant risk factor was previous antibiotic use (OR 18.4; 95% CI 6.2-54.6). The major risk factor for acquisition of PRSP in this study population is recent antibiotic use. Decreased antibiotic use would reduce risk of acquisition of PRSP.en_US
dc.description.affiliationDepartment of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationDejthevapor C, Vibhagool A, Thakkinstian A, Sirinavi S, Vorachit M. Risk factors for penicillin-resistant Streptococcus pneumoniae acquisition in patients in Bangkok. The Southeast Asian Journal of Tropical Medicine and Public Health. 2000 Dec; 31(4): 679-83en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/32373
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2000_31_4/11-2576.pdfen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHospitals, Teachingen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPenicillin Resistanceen_US
dc.subject.meshPneumococcal Infections --epidemiologyen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshStreptococcus pneumoniae --drug effectsen_US
dc.subject.meshThailand --epidemiologyen_US
dc.titleRisk factors for penicillin-resistant Streptococcus pneumoniae acquisition in patients in Bangkok.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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