Risk factors for penicillin-resistant Streptococcus pneumoniae acquisition in patients in Bangkok.
dc.contributor.author | Dejthevapor, C | en_US |
dc.contributor.author | Vibhagool, A | en_US |
dc.contributor.author | Thakkinstian, A | en_US |
dc.contributor.author | Sirinavi, S | en_US |
dc.contributor.author | Vorachit, M | en_US |
dc.date.accessioned | 2009-05-27T15:16:39Z | |
dc.date.available | 2009-05-27T15:16:39Z | |
dc.date.issued | 2000-12-21 | en_US |
dc.description | The Southeast Asian Journal of Tropical Medicine and Public Health. | en_US |
dc.description.abstract | To identify risk factors for acquisition of penicillin-resistant Streptococcus pneumoniae (PRSP) in patients in Bangkok, using a case-control study, the study included patients with clinical specimens which grew S. pneumoniae during January to December 1997, treated at a teaching hospital in Bangkok. Penicillin susceptibility was determined by E-test and strains with MIC of > 0.1 microg/ml were considered resistant. Cases were the patients who had PRSP, and patients who had penicillin-susceptible S. pneumoniae (PSSP) were controls. The study variables included age 15 years or younger, immunocompromised status, ventilatory support, and antibiotic use or hospitalization within the previous 3 months. There were 73 cases and 51 controls. Their ages were 0 to 87 years, with median age of cases 4 and controls 49 years. Pneumonia was the most common type of infection, being 47% in cases and 45% in controls. Univariate analysis revealed significant association of PRSP acquisition with previous antibiotic use (p<0.0001), age < or = 15 years (p=0.001) and previous hospitalization (p=0.002). Logistic regression analysis in order to adjust for confounding effects showed that the only significant risk factor was previous antibiotic use (OR 18.4; 95% CI 6.2-54.6). The major risk factor for acquisition of PRSP in this study population is recent antibiotic use. Decreased antibiotic use would reduce risk of acquisition of PRSP. | en_US |
dc.description.affiliation | Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. | en_US |
dc.identifier.citation | Dejthevapor C, Vibhagool A, Thakkinstian A, Sirinavi S, Vorachit M. Risk factors for penicillin-resistant Streptococcus pneumoniae acquisition in patients in Bangkok. The Southeast Asian Journal of Tropical Medicine and Public Health. 2000 Dec; 31(4): 679-83 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/32373 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.tm.mahidol.ac.th/seameo/2000_31_4/11-2576.pdf | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Aged, 80 and over | en_US |
dc.subject.mesh | Case-Control Studies | en_US |
dc.subject.mesh | Child | en_US |
dc.subject.mesh | Child, Preschool | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Hospitals, Teaching | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Infant | en_US |
dc.subject.mesh | Infant, Newborn | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Penicillin Resistance | en_US |
dc.subject.mesh | Pneumococcal Infections --epidemiology | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.subject.mesh | Streptococcus pneumoniae --drug effects | en_US |
dc.subject.mesh | Thailand --epidemiology | en_US |
dc.title | Risk factors for penicillin-resistant Streptococcus pneumoniae acquisition in patients in Bangkok. | en_US |
dc.type | Journal Article | en_US |
dc.type | Research Support, Non-U.S. Gov't | en_US |