Adjuvant radiation therapy in gall bladder cancers: 10 years experience at Tata Memorial Hospital.

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dc.contributor.authorMahantshetty, Umesh Men_US
dc.contributor.authorPalled, S Ren_US
dc.contributor.authorEngineer, Ren_US
dc.contributor.authorHomkar, Gen_US
dc.contributor.authorShrivastava, S Ken_US
dc.contributor.authorShukla, P Jen_US
dc.date.accessioned2006-04-14en_US
dc.date.accessioned2009-06-01T16:27:00Z
dc.date.available2006-04-14en_US
dc.date.available2009-06-01T16:27:00Z
dc.date.issued2006-04-14en_US
dc.description.abstractINTRODUCTION AND PURPOSE: In gall bladder cancers, even after curative surgery, survivals are dismal and loco-regional failure accounts for 40-86%. Although these are considered radio-resistant, adjuvant radiation, with or without chemotherapy, has been tried to improve loco-regional control and overall survival rates. With an aim to evaluate the natural history of gall bladder cancers, role of radiation therapy (RT) and prognostication, a retrospective analysis was undertaken. MATERIALS AND METHODS: Between 1991-2000, 60 patients with gall bladder cancer, treated with radical intent, were evaluated. Patients details including history, physical examination, liver function tests, ultrasonography of the abdomen and chest X-ray; and CT scan Abdomen if done, were noted. In patients who underwent surgery, surgical details, histopathology and pathological staging, were recorded. The details of post-operative adjuvant treatment, including radiation therapy details, as well as chemotherapeutic agents, number of cycles and type of infusion [bolus/infusion], were noted. RESULTS: Sixty patients underwent surgery. On histopathological staging, 28 patients (46.5%) had stage II, 19 (32%) had stage III, 12 (20%) had stage-I and 1 patient had stage IV disease. Thirteen (21%) patents did not receive any adjuvant treatment, 32 (53%) patients received adjuvant RT alone, 8(14%) received post-operative CT+RT and 7 (12%) patients received CT alone. With a median follow-up of 18 months (12-124 months), 27 (45%) patients were disease free, 11 (19%) had local failures, 7 (11%) had loco-regional, 7 (11%) loco-regional+distant, 4 (7%) distant and 4 (7%) patients had local+distant failures. The Overall Disease Free Survival (DFS) and overall survival was 30% and 25%, at 5 years, respectively. Stage grouping ('P' = 0.007), Pathological T ('P' = 0.01) had significant impact on DFS on univariate analysis, where as histological grade ('P' = 0.06) showed trend towards significance. CONCLUSION: Gall bladder cancers are aggressive and lethal. Early diagnosis and curative surgery, followed by appropriate adjuvant radiation therapy, may improve survivals, with no established consensus till date. Following curative surgery, pathological T stage and stage grouping, are the significant prognostic factors for outcome.en_US
dc.description.affiliationDepartment of Radiation Oncology, Tata Memorial Hospital, Mumbai, India. drumeshm@yahoo.comen_US
dc.identifier.citationMahantshetty UM, Palled SR, Engineer R, Homkar G, Shrivastava SK, Shukla PJ. Adjuvant radiation therapy in gall bladder cancers: 10 years experience at Tata Memorial Hospital. Journal of Cancer Research and Therapeutics. 2006 Apr-Jun; 2(2): 52-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/111560
dc.language.isoengen_US
dc.source.urihttps://www.cancerjournal.neten_US
dc.subject.meshAntineoplastic Agents --therapeutic useen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshDigestive System Surgical Proceduresen_US
dc.subject.meshGallbladder Neoplasms --mortalityen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshRadiotherapy, Adjuvanten_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSurvival Analysisen_US
dc.titleAdjuvant radiation therapy in gall bladder cancers: 10 years experience at Tata Memorial Hospital.en_US
dc.typeJournal Articleen_US
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