Abnormal hemostasis in dengue hemorrhagic fever.

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dc.contributor.authorHathirat, Pen_US
dc.contributor.authorIsarangkura, Pen_US
dc.contributor.authorSrichaikul, Ten_US
dc.contributor.authorSuvatte, Ven_US
dc.contributor.authorMitrakul, Cen_US
dc.date.accessioned2009-05-27T16:19:53Z
dc.date.available2009-05-27T16:19:53Z
dc.date.issued1993-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health. 51 references.en_US
dc.description.abstractAbstract. Abnormal hemostasis in dengue hemorrhagic fever includes:- 1. Vasculopathy which occurs during the early febrile to pre-shock and shock phase. The evidences support are: 1.1 Increased anaphylatoxin, released by complement activation causing leakage of intravascular fluid in to serous space. 1.2 Positive tourniquet test, some of which occur preceeding thrombocytopenia in the acute phase of DHF. 1.3 Excessive increased in PGI2 which is the most potent vasodilator and platelet aggregation inhibitor. 2. Platelets: 2.1 Thrombocytopenia due to 2.1.1 The bone marrow hypocellularity with increased in all forms of megakaryocytes but the vacuolated and disintegrated ones. 2.1.2 Destruction by the liver and spleen. 2.1.3 Immune-mediated injury as demonstration of dengue antibody complexes on the platelet surface. 2.1.4 The in vitro spontaneous aggregation to vascular endothelial cell pre-infected by dengue virus inducing platelet aggregation, causing lysis and platelet destruction. 2.2 Dysfunction shown by 2.2.1 Increased release of betathromboglobulin (BTG), PF4 and PGI2. 2.2.2 In vitro hypoaggregation stimulated by ADP and defect in ADP-releasing ability. 3. Coagulopathy including: 3.1 Prothrombin complex deficiency due to liver damage. 3.2 Consumptive coagulopathy due to the activation by mononuclear phagocytes, PF3 released from platelet aggregation. DIC is seen in prolonged shock cases of DSS.en_US
dc.description.affiliationDepartment of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationHathirat P, Isarangkura P, Srichaikul T, Suvatte V, Mitrakul C. Abnormal hemostasis in dengue hemorrhagic fever. The Southeast Asian Journal of Tropical Medicine and Public Health. 1993 ; 24 Suppl 1(): 80-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34963
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshDengue --blooden_US
dc.subject.meshHemostasis --physiologyen_US
dc.subject.meshHumansen_US
dc.titleAbnormal hemostasis in dengue hemorrhagic fever.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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