Grading of marrow fibrosis in chronic myeloid leukemia--a comprehensive approach.

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dc.contributor.authorRao, Seemaen_US
dc.contributor.authorSen, Rajeeven_US
dc.contributor.authorSingh, Sunitaen_US
dc.contributor.authorGhalaut, Partap Singhen_US
dc.contributor.authorArora, Brij Balaen_US
dc.date.accessioned2005-07-10en_US
dc.date.accessioned2009-05-29T11:55:38Z
dc.date.available2005-07-10en_US
dc.date.available2009-05-29T11:55:38Z
dc.date.issued2005-07-10en_US
dc.description.abstractIn the course of Chronic myeloid leukemia (CML), appearance of increased number of blasts may herald evolution of accelerated phase as well as onset of marrow fibrosis (MF) thereby necessitating the need to perform trephine biopsy for correct diagnosis and appropriate treatment. In the existing grading systems of MF, a comprehensive view has not been taken of the variability of density and area occupied by reticulin and collagen fibres. To overcome this shortcoming, we quantitated the reticulin and collagen content of marrow, its pattern of distribution and percentage area occupied by each type of fibres in every individual case. We performed 50 bone marrow (BM) trephine biopsies in patients of CML in order to assess the incidence and degree of MF. Various grades of MF were correlated with peripheral smear including blast count, bone marrow aspirate and LAP score of the case. A positive correlation was found between increasing grades of MF and number of megakaryocytes in the BM.en_US
dc.description.affiliationDepartment of Pathology of VMMC & Safdarjung Hospital csydr@rediffmail.comen_US
dc.identifier.citationRao S, Sen R, Singh S, Ghalaut PS, Arora BB. Grading of marrow fibrosis in chronic myeloid leukemia--a comprehensive approach. Indian Journal of Pathology & Microbiology. 2005 Jul; 48(3): 341-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/74043
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBiopsyen_US
dc.subject.meshBone Marrow --pathologyen_US
dc.subject.meshBone Marrow Cells --pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive --epidemiologyen_US
dc.subject.meshMegakaryocytes --pathologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrimary Myelofibrosis --epidemiologyen_US
dc.titleGrading of marrow fibrosis in chronic myeloid leukemia--a comprehensive approach.en_US
dc.typeJournal Articleen_US
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