Comparison of terbutaline and salbutamol inhalation in children with mild or moderate acute exacerbation of asthma.

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dc.contributor.authorChandra, Prakashen_US
dc.contributor.authorPaliwal, Lokeshen_US
dc.contributor.authorLodha, Rakeshen_US
dc.contributor.authorKabra, S Ken_US
dc.date.accessioned2004-11-02en_US
dc.date.accessioned2009-05-30T10:19:33Z
dc.date.available2004-11-02en_US
dc.date.available2009-05-30T10:19:33Z
dc.date.issued2004-11-02en_US
dc.description.abstractOBJECTIVE: To compare the clinical efficacy and side effects of terbutaline and salbutamol administered by metered dose inhaler and holding chamber in the mild to moderate acute exacerbations of asthma in children. METHODS: The study subjects were children in the age group of 5- 15 years who presented with a mild or moderate acute exacerbation of asthma. Baseline assessment included clinical parameters and spirometry. The children were then randomized to receive salbutamol or terbutaline. Three puffs each of either 100 mcg salbutamol or 250 mcg of terbutaline were administered using 750 ml holding chamber with valve. Thirty minutes after drug administration, the children were reevaluated for clinical parameters and spirometry. RESULTS: Of the total 60 subjects studied, 31 were administered terbutaline and 29 salbutamol. The baseline spirometric parameters were comparable. After drug administration, all the studied variables showed significant improvement within each group. However, there were no statistically significant differences when the two groups were compared with each other. There was no significant difference in the side effects between two groups. CONCLUSION: Terbutaline and salbutamol, when administered by MDI with holding chamber, are equally efficacious in children with mild or moderate acute exacerbation of asthma.en_US
dc.description.affiliationDepartment of Pediatrics, All India Institute of Medical Sciences, New Delhi 110-029, India.en_US
dc.identifier.citationChandra P, Paliwal L, Lodha R, Kabra SK. Comparison of terbutaline and salbutamol inhalation in children with mild or moderate acute exacerbation of asthma. Indian Journal of Pediatrics. 2004 Nov; 71(11): 961-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/78528
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAdministration, Inhalationen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAlbuterol --administration & dosageen_US
dc.subject.meshAsthma --diagnosisen_US
dc.subject.meshChilden_US
dc.subject.meshConfidence Intervalsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshNebulizers and Vaporizersen_US
dc.subject.meshProbabilityen_US
dc.subject.meshRecurrenceen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshSpirometryen_US
dc.subject.meshTerbutaline --administration & dosageen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleComparison of terbutaline and salbutamol inhalation in children with mild or moderate acute exacerbation of asthma.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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