AL Amyloidosis with Polycythemia, Leucocytosis and Thrombocytosis : A Case Report
Loading...
Date
2023-04
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Medical Association
Abstract
A young lady presented to us with clinical and biochemical evidence of Nephrotic Syndrome. Her laboratory investigations also revealed Erythrocytosis, Leucocytosis and Thrombocytosis. A renal biopsy revealed a diagnosis of Amyloidosis which was further characterized as AL amyloidosis with further investigations (kappa chain monoclonal gammopathy). She was started with appropriate therapy and she showed significant decline in her monoclonal Proteins on follow up. Her Erythrocytosis, Leucocytosis and Thrombocytosis also normalized with the decline in the levels of monoclonal light chains. We postulate a link between the monoclonal protein associated growth factors and inflammatory markers which were responsible for this unique association between AL Amyloidosis and tri-lineage hematopoietic cell proliferation.
Description
Keywords
AL Amyloidosis, Nephrotic Syndrome, Polycythemia, Leucocytosis, Thrombocytosis.
Citation
Anandh Urmila, Vaswani Bharat, Hurmath Syeda. AL Amyloidosis with Polycythemia, Leucocytosis and Thrombocytosis : A Case Report. Journal of The Indian Medical Association. 2023 Apr; 121(4): 68-70