Efficacy of intense pulsed light therapy on signs and symptoms of dry eye disease: A meta-analysis and systematic review

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dc.contributor.authorQin, Guanghaoen_US
dc.contributor.authorChen, Jiayanen_US
dc.contributor.authorLi, Liangzheen_US
dc.contributor.authorZhang, Qingen_US
dc.contributor.authorXu, Lingen_US
dc.contributor.authorYu, Sileen_US
dc.contributor.authorHe, Weien_US
dc.contributor.authorHe, Xingruen_US
dc.contributor.authorPazo, Emmanuel Ericen_US
dc.date.accessioned2023-08-25T06:36:42Z
dc.date.available2023-08-25T06:36:42Z
dc.date.issued2023-04
dc.description.abstractThis study reviewed the efficacy and safety of intense pulsed light (IPL) for the treatment of dry eye disease (DED). The PubMed database was used to conduct the literature search, which used the keywords “intense pulsed light” and “dry eye disease”. After the authors evaluated the articles for relevancy, 49 articles were reviewed. In general, all treatment modalities were proven to be clinically effective in reducing dry eye (DE) signs and symptoms; however, the level of improvement and persistence of outcomes differed amongst them. Meta-analysis indicated significant improvement in the Ocular Surface Disease Index (OSDI) scores post-treatment with a standardized mean difference (SMD) = ?1.63; confidence interval (CI): ?2.42 to ?0.84. Moreover, a meta-analysis indicated a significant improvement in tear break-up time (TBUT) test values with SMD = 1.77; CI: 0.49 to 3.05. Research suggests that additive therapies, such as meibomian gland expression (MGX), sodium hyaluronate eye drops, heated eye mask, warm compress, lid hygiene, lid margin scrub, eyelid massage, antibiotic drops, cyclosporine drops, omega-3 supplements, steroid drops, and warm compresses along with IPL, have been found to work in tandem for greater effectiveness; however, in clinical practice, its feasibility and cost-effectiveness have to be taken into consideration. Current findings suggest that IPL therapy is suitable when lifestyle modifications such as reducing or eliminating the use of contact lenses, lubricating eye drops/gels, and warm compresses/eye masks fail to improve signs and symptoms of DE. Moreover, patients with compliance issues have been shown to benefit well as the effects of IPL therapy is sustained for over several months. DED is a multifactorial disorder, and IPL therapy has been found to be safe and efficient in reducing its signs and symptoms of meibomian gland dysfunction (MGD)-related DE. Although the treatment protocol varies among authors, current findings suggest that IPL has a positive effect on the signs and symptoms of MGD-related DE. However, patients in the early stages can benefit more from IPL therapy. Moreover, IPL has a better maintenance impact when used in conjunction with other traditional therapies. Further research is needed to assess cost-utility analysis for IPL.en_US
dc.identifier.affiliationsDepartment of Ophthalmology, He Eye Specialist Hospital, Liaoning, Shenyang, Chinaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, Tianjin Medical University Eye Hospital, Tianjin, Chinaen_US
dc.identifier.affiliationsSchool of Public Health, He University, Shenyang, Liaoning, Shenyang, Chinaen_US
dc.identifier.citationQin Guanghao, Chen Jiayan, Li Liangzhe, Zhang Qing, Xu Ling, Yu Sile, He Wei, He Xingru, Pazo Emmanuel Eric. Efficacy of intense pulsed light therapy on signs and symptoms of dry eye disease: A meta-analysis and systematic review. Indian Journal of Ophthalmology. 2023 Apr; 71(4): 1316-1325en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224945
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber4en_US
dc.relation.volume71en_US
dc.source.urihttps://doi.org/10.4103/IJO.IJO_2987_22en_US
dc.subjectDry eyeen_US
dc.subjectintense pulsed lighten_US
dc.subjectmeibomian gland dysfunctionen_US
dc.titleEfficacy of intense pulsed light therapy on signs and symptoms of dry eye disease: A meta-analysis and systematic reviewen_US
dc.typeJournal Articleen_US
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