β-Caryophyllene causes remyelination and modifies cytokines expression in C57BL/6 mice with experimental autoimmune encephalomyelitis

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dc.contributor.authorMesquita, Harleson Lopesen_US
dc.contributor.authorFontes, Livia Beatriz Almeidaen_US
dc.contributor.authorCinsa, Laetitia Alvesen_US
dc.contributor.authorAdemar, Alves Da Silva Filhoen_US
dc.contributor.authorAkinori, Cardozo Nagatoen_US
dc.contributor.authorBeatriz, Julião Vieira Aarestrupen_US
dc.contributor.authorJosé, Otávio do Amaral Corrêaen_US
dc.contributor.authorFernando, Monteiro Aarestrupen_US
dc.date.accessioned2020-10-16T08:55:37Z
dc.date.available2020-10-16T08:55:37Z
dc.date.issued2019-07
dc.description.abstractThe aim of this study is to evaluate the effect of β-Caryophyllene (BCP) on the production of IL-17, transcription factors(T-bet and GATA-3), and remyellination in C57BL/6 mice induced for experimental autoimmune encephalomyelitis(EAE), the model for studying pathogenesis and new therapies for multiple sclerosis. EAE was induced in threegroups of C57BL/6, with administration of BCP in two groups (25 and 50 mg/kg/day) by gavage, after the 10th dayof induction. At 9 days of treatment, mice were euthanized and CNS was removed for the analysis. The profiles ofIL-17, T-bet, GATA-3, and the possible remyelination properties were investigated in the central nervous system(CNS) by immunohistochemistry and Weigert–Pal–Russel’s method, respectively. BCP group (50 mg/kg/day) showeda reduction of IL-17 in brain, cerebellum, and medulla (p < 0.05) and a decrease of T-bet (p < 0.05) in medullaand cerebellum, while GATA-3 was increased (p < 0.05) in cerebellum. In both BCP-treated groups were observedremyelination and better organization of myelin. In conclusion, BCP possesses markedly in vivo anti-inflammatoryand neuroprotective activities and remyelination properties in EAE-mice.en_US
dc.identifier.affiliationsLaboratory of Experimental Imunology and Patology, CBR, Federal University of Juiz de Fora, Juiz de Fora, Brazilen_US
dc.identifier.affiliationsLaboratory of Experimental Imunology and Patology, CBR, Federal University of Juiz de Fora, Juiz de Fora, Brazil.en_US
dc.identifier.affiliationsLaboratory of Experimental Imunology and Patology, CBR, Federal University of Juiz de Fora, Juiz de Fora, Brazilen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Sciences, Faculty of Phamarcy, Federal University of Juiz de Fora, Juiz de Fora, Brazilen_US
dc.identifier.affiliationsLaboratory of Experimental Imunology and Patology, CBR, Federal University of Juiz de Fora, Juiz de Fora, Brazil.en_US
dc.identifier.affiliationsLaboratory of Experimental Imunology and Patology, CBR, Federal University of Juiz de Fora, Juiz de Fora, Brazil.en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Sciences, Faculty of Phamarcy, Federal University of Juiz de Fora, Juiz de Fora, Brazilen_US
dc.identifier.affiliationsLaboratory of Experimental Imunology and Patology, CBR, Federal University of Juiz de Fora, Juiz de Fora, Brazilen_US
dc.identifier.citationMesquita Harleson Lopes, Fontes Livia Beatriz Almeida, Cinsa Laetitia Alves, Ademar Alves Da Silva Filho, Akinori Cardozo Nagato, Beatriz Julião Vieira Aarestrup, José Otávio do Amaral Corrêa, Fernando Monteiro Aarestrup. β-Caryophyllene causes remyelination and modifies cytokines expression in C57BL/6 mice with experimental autoimmune encephalomyelitis. Journal of Applied Pharmaceutical Science. 2019 Jul; 2019 Jul: 027-033en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210400
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber7en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2019.90704en_US
dc.subjectβ-Caryophylleneen_US
dc.subjectmultiple sclerosisen_US
dc.subjectexperimental autoimmune encephalomyelitis.en_US
dc.titleβ-Caryophyllene causes remyelination and modifies cytokines expression in C57BL/6 mice with experimental autoimmune encephalomyelitisen_US
dc.typeJournal Articleen_US
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