Experimental studies on the treatment of frostbite in rats.

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dc.contributor.authorPurkayastha, S Sen_US
dc.contributor.authorChhabra, P Cen_US
dc.contributor.authorVerma, S Sen_US
dc.contributor.authorSelvamurthy, Wen_US
dc.date.accessioned1993-08-01en_US
dc.date.accessioned2009-05-27T07:18:44Z
dc.date.available1993-08-01en_US
dc.date.available2009-05-27T07:18:44Z
dc.date.issued1993-08-01en_US
dc.description.abstractThe effect of treatment by high dose of vitamin C, rapid rewarming by 37 degrees C water alone and with vitamin C, rapid rewarming by 37 degrees C decoction of Indian black tea alone and with vitamin C for experimentally produced frostbite was evaluated in 6 groups (25 each) of rats. Frostbite was produced experimentally in the hind limbs by exposing the animals at -15 degrees C for 1h using the harness technique. The degree of injury was assessed and classified on the basis of tissue necrosis at the end of 15 days. Administration of high dose of vitamin C for prolonged period and rapid rewarming at 37 degrees C water bath immediately after cold exposure apparently reduced the tissue damage. High dose of vitamin C therapy preceded by rapid rewarming in plain water showed additional benefit. Rapid rewarming in decoction of Indian tea resulted in identical beneficial effect. The degree of tissue preservation was highest with rapid rewarming in tea decoction followed by high dose of vitamin C.en_US
dc.description.affiliationDefence Institute of Physiology & Allied Sciences, Delhi Cantt.en_US
dc.identifier.citationPurkayastha SS, Chhabra PC, Verma SS, Selvamurthy W. Experimental studies on the treatment of frostbite in rats. Indian Journal of Medical Research. 1993 Aug; 98(): 178-84en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/20184
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAscorbic Acid --therapeutic useen_US
dc.subject.meshFemaleen_US
dc.subject.meshFrostbite --therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRewarming --methodsen_US
dc.subject.meshTeaen_US
dc.subject.meshWateren_US
dc.titleExperimental studies on the treatment of frostbite in rats.en_US
dc.typeJournal Articleen_US
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