Pharmacokinetics of ofloxacin in drug-resistant tuberculosis.

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dc.contributor.authorChulavatnatol, Suvatnaen_US
dc.contributor.authorChindavijak, Busbaen_US
dc.contributor.authorChierakul, Nitipatanaen_US
dc.contributor.authorKlomsawat, Duangraten_US
dc.date.accessioned2009-05-27T18:39:01Z
dc.date.available2009-05-27T18:39:01Z
dc.date.issued2003-08-02en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractThe pharmacokinetics of ofloxacin were investigated in 11 drug-resistant pulmonary tuberculosis (TB) patients with a mean age (SD) of 38.09 (11.97) years. All patients received ofloxacin 10 mg/kg once daily combined with other active anti-TB drugs. Following an 8-h overnight fast, serum samples were drawn prior to and from 0.25 up to 24 hours after dosing. Serum ofloxacin concentrations were determined by high performance liquid chromatography (HPLC) assay. Pharmacokinetics of ofloxacin were well described by a linear, 2-compartment open model with first-order absorption and first-order elimination. Mean +/- SD of Cmax was 9.61 +/- 2.17 microg/ml occurred at 1.68 +/- 1.21 hours. Means +/- SD of AUC(0-24) and AUC(0-infinity) were 70.57 +/- 26.40 and 82.45 +/- 43.64 microg x h/ml, respectively. Ofloxacin distributed widely with a mean +/- SD of Vss/F of 1.37 +/- 0.24 L/kg. Mean +/- SD of CL/F was 8.19 +/- 2.53 L/h, whereas mean +/- SD of T(1/2beta) and mean residence time were 8.03 +/- 3.37 and 10.77 +/- 4.55 hours, respectively. The free Cmax/MIC of Mycobacterium tuberculosis of 7.7-15.4:1 was estimated. These suggested that ofloxacin 10 mg/kg once daily combined with other active anti-TB drugs provides sufficient Cmax/MIC ratio and long T(1/2beta) which supported its use in drug-resistant TB.en_US
dc.description.affiliationDepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.en_US
dc.identifier.citationChulavatnatol S, Chindavijak B, Chierakul N, Klomsawat D. Pharmacokinetics of ofloxacin in drug-resistant tuberculosis. Journal of the Medical Association of Thailand. 2003 Aug; 86(8): 781-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/39573
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshAnti-Infective Agents --administration & dosageen_US
dc.subject.meshAntitubercular Agents --administration & dosageen_US
dc.subject.meshArea Under Curveen_US
dc.subject.meshChromatography, High Pressure Liquiden_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOfloxacin --administration & dosageen_US
dc.subject.meshPyrazinamide --therapeutic useen_US
dc.subject.meshRifampin --therapeutic useen_US
dc.subject.meshTuberculosis, Multidrug-Resistant --drug therapyen_US
dc.titlePharmacokinetics of ofloxacin in drug-resistant tuberculosis.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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