Triiodothyronine and melatonin influence antioxidant defense mechanism in a teleost Anabas testudineus (Bloch): in vitro study.

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dc.contributor.authorSreejith, Pen_US
dc.contributor.authorBeyo, R Sen_US
dc.contributor.authorDivya, Len_US
dc.contributor.authorVijayasree, A Sen_US
dc.contributor.authorManju, Men_US
dc.contributor.authorOommen, O Ven_US
dc.date.accessioned2007-06-27en_US
dc.date.accessioned2009-05-27T09:15:06Z
dc.date.available2007-06-27en_US
dc.date.available2009-05-27T09:15:06Z
dc.date.issued2007-06-27en_US
dc.description.abstractThe effect of the hormones triiodothyronine (T3) and melatonin on antioxidant defense system was studied in 6-propyl thiouracil (6-PTU)-treated or photoperiod-exposed teleost Anabas testudineus. 6-PTU (2 microg/g) treatment or photoperiod exposure (24 h) increased malondialdehyde (MDA) and conjugated dienes (CD) concentrations, indicating increased lipid peroxidation (LPO) in the experimental conditions. T3 or melatonin (10(-6) M) treatment for 15 min in vitro in PTU-treated fish reversed the activity of superoxide dismutase (SOD), catalase and glutathione content. T3-treated group showed no change in glutathione peroxidase (GPx) activity, whereas melatonin treatment decreased its activity. T3 inhibited glutathione reductase (GR) activity. Photoperiod exposure (physiological pinealotomy) induced a stressful situation in this teleost, as evidenced by LPO products and antioxidant enzyme activities. Melatonin and T3 treatment for 15 min in vitro also reversed the effect of photoperiod on peroxidation products and the SOD and catalase activities. GR activity decreased in photoperiod-exposed group and melatonin and T3 treatment reversed the activities. The antioxidant enzymes responded to the stress situation after 6-PTU treatment and photoperiod exposure by altering their activities. The study suggested an independent effect of T3 and melatonin on antioxidant defence mechanism in different physiological situations in fish.en_US
dc.description.affiliationDepartment of Zoology, University of Kerala, Kariavattom, Thiruvananthapuram- 695 581, Kerala, India.en_US
dc.identifier.citationSreejith P, Beyo RS, Divya L, Vijayasree AS, Manju M, Oommen OV. Triiodothyronine and melatonin influence antioxidant defense mechanism in a teleost Anabas testudineus (Bloch): in vitro study. Indian Journal of Biochemistry & Biophysics. 2007 Jun; 44(3): 164-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/26933
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants --metabolismen_US
dc.subject.meshFishesen_US
dc.subject.meshFree Radicalsen_US
dc.subject.meshGlutathione Peroxidase --metabolismen_US
dc.subject.meshHypothyroidism --metabolismen_US
dc.subject.meshLighten_US
dc.subject.meshLipid Peroxidationen_US
dc.subject.meshLiver --metabolismen_US
dc.subject.meshMelatonin --metabolismen_US
dc.subject.meshPineal Gland --metabolismen_US
dc.subject.meshPropylthiouracil --chemistryen_US
dc.subject.meshThyroid Gland --metabolismen_US
dc.subject.meshTriiodothyronine --pharmacologyen_US
dc.titleTriiodothyronine and melatonin influence antioxidant defense mechanism in a teleost Anabas testudineus (Bloch): in vitro study.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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