Gonadotropin-Dependent Precocious Puberty: Single-Center Experience From Western India
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Date
2023-06
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Academy of Pediatrics
Abstract
Objective: To describe the characteristics of gonadotropin-dependent precocious puberty (GDPP) in Indian children. Methods: Clinical profiles of GDPP (n=78, 61 females) and premature thelarche (n=12) from a single center in Western India were retrospectively studied. Results: Pubertal onset was earlier in boys than girls (29 vs 75 months, respectively; P=0.008). The basal luteinizing hormone (LH) was ?0.3 mIU/mL, except 18% of GDPP girls. At 60 minutes after GnRHa-stimulation, all patients (except one girl) had LH ?5 mIU/mL. The GnRHa-stimulated LH/FSH ratio was ?0.34 at 60 minutes in girls with GDPP unlike premature thelarche. Only one girl had an allergic reaction to long-acting GnRH agonist. Among GnRH agonist-treated girls (n=24), the predicted final adult height was -1.67±1.5 SDS, whereas the attained final height was -0.25±1.48 SDS. Conclusion: We establish the safety and efficacy of long acting GnRH agonist therapy in Indian children with GDPP. The 60-minute stimulated serum LH/FSH of ?0.34 differentiated GDPP from premature thelarche.
Description
Keywords
GnRHa stimulation test, Management, Premature thelarche, Pubarche.
Citation
Phadte Aditya, Sarathi Vijaya, Budyal Sweta, Lila Anurag, Memon Saba Samad, Karlekar Manjiri, Patil Virendra, Shah Nalini, Bandgar Tushar. Gonadotropin-Dependent Precocious Puberty: Single-Center Experience From Western India. Indian Pediatrics. 2023 Jun; 60(6): 463-466