The association of co-expression of CD44v4/MMP-9 with different nodal status in high-grade breast carcinoma patients.

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dc.contributor.authorThanakit, Voranuchen_US
dc.contributor.authorSampatanukul, Picheten_US
dc.contributor.authorRuangvejvorachai, Preechaen_US
dc.contributor.authorKeelawat, Somboonen_US
dc.date.accessioned2009-05-27T20:53:01Z
dc.date.available2009-05-27T20:53:01Z
dc.date.issued2005-09-21en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractBACKGROUND: Breast carcinoma is one of the most common tumors in female patients, and its metastasis is a major cause of death. An experimental model has recently found the association of CD44 with MMP-9 that facilitates tumor cell invasion and metastasis. MATERIAL AND METHOD: The CD44v4 and MMP-9 were performed on tissue in paraffin blocks of 50 cases of high-grade breast carcinoma with node positive and 50 cases with node negative. RESULTS: Increased expression of MMP-9(60%) significantly observed in high-grade breast carcinoma patients with node positive (p = 0. 004), whereas CD44v4 displays no significant difference between the two groups (p-value = 0.81). Significant co-expression of CD44v4+ / MMP-9+ (46%) was observed and correlated with node-positive patients whereas the CD44v4+ / MMP-9- (54%) express in node-negative patient (p-value = 0.01). CONCLUSION: The solely expression of CD44v4 does not associate with node status. MMP-9 plays an important role to enhance breast carcinoma cell invasion and associates with lymph node metastasis. The combined expression of CD44v4 (overexpression) and derangement of MMP-9 expression was significantly associated with nodal status.en_US
dc.description.affiliationDepartment of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. voranewt@yahoo.comen_US
dc.identifier.citationThanakit V, Sampatanukul P, Ruangvejvorachai P, Keelawat S. The association of co-expression of CD44v4/MMP-9 with different nodal status in high-grade breast carcinoma patients. Journal of the Medical Association of Thailand. 2005 Sep; 88 Suppl 4(): S30-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/43807
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAntigens, CD44 --metabolismen_US
dc.subject.meshBreast Neoplasms --enzymologyen_US
dc.subject.meshCarcinoma --enzymologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshLymph Nodes --enzymologyen_US
dc.subject.meshLymphatic Metastasisen_US
dc.subject.meshMatrix Metalloproteinase 9 --metabolismen_US
dc.titleThe association of co-expression of CD44v4/MMP-9 with different nodal status in high-grade breast carcinoma patients.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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