An Investigative Study of Prothrombin Time, Activated Partial Thromboplastin Time and Antithrombin Levels in Patients with Ischaemic Stroke

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dc.contributor.authorNnachi, OCen_US
dc.contributor.authorEzenwenyi, IPen_US
dc.contributor.authorAkulue, JCen_US
dc.contributor.authorNnachi, OAen_US
dc.contributor.authorNwadum, FEen_US
dc.contributor.authorOnoh, TJen_US
dc.contributor.authorEzeokoli, OEen_US
dc.contributor.authorUgwu, CG.en_US
dc.date.accessioned2025-05-09T06:23:05Z
dc.date.available2025-05-09T06:23:05Z
dc.date.issued2024-09
dc.description.abstractBackground: The haemostatic system maintains a balance between prothrombotic and antithrombotic components in the body. The role of this system in ischaemic stroke is not certain. Objective: Prothrombin time (PT) and Activated Partial Thromboplastin Time(APTT) are widely used screening tests to assess the haemostatic cascade. We sought to evaluate the relevance of these test and antithrombin (AT) levels in patients with ischaemic stroke. Methods: AT, platelet count, PT and APTT tests were carried out for 65 patients with ischaemic stroke and 65 controls with no history of stroke. Results: The mean age of stroke subjects was 60.4 ± 12.3yrs. PT and APTT in the test and control groups were similar and Antithrombin levels did not show significant difference. But there was a significant association between functional AT deficiency and diabetes mellitus in the ischaemic stroke group. A significant negative correlation existed between functional AT activity and prothrombin and between AT Ag levels and APTT Conclusion: There was no difference in the Antithrombin levels, PT and APTT values in patients with ischaemic stroke and those without a history of stroke and carrying out these tests routinely to assess hypercoagulable states in ischaemic stroke patients may not have any diagnostic value in our population.en_US
dc.identifier.affiliationsDepartment of Haematology, Alex Ekwueme Federal University Teaching Hospital Abakaliki.Nigeriaen_US
dc.identifier.affiliationsDepartment of Haematology, Alex Ekwueme Federal University Teaching Hospital Abakaliki.Nigeriaen_US
dc.identifier.affiliationsDepartment of Haematology, Alex Ekwueme Federal University Teaching Hospital Abakaliki.Nigeriaen_US
dc.identifier.affiliationsDepartment of Haematology, Alex Ekwueme Federal University Teaching Hospital Abakaliki.Nigeriaen_US
dc.identifier.affiliationsDepartment of Medical Laboratory Sciences, David Umahi Federal University of Health Sciences, Uburu, Nigeriaen_US
dc.identifier.affiliationsDepartment of Haematology, Alex Ekwueme Federal University Teaching Hospital Abakaliki.Nigeriaen_US
dc.identifier.affiliationsDepartment of Haematology, Alex Ekwueme Federal University Teaching Hospital Abakaliki.Nigeriaen_US
dc.identifier.affiliationsDepartment of Haematology, Alex Ekwueme Federal University Teaching Hospital Abakaliki.Nigeriaen_US
dc.identifier.citationNnachi OC, Ezenwenyi IP, Akulue JC, Nnachi OA, Nwadum FE, Onoh TJ, Ezeokoli OE, Ugwu CG.. An Investigative Study of Prothrombin Time, Activated Partial Thromboplastin Time and Antithrombin Levels in Patients with Ischaemic Stroke. International Blood Research & Reviews. 2024 Sep; 15(3): 22-28en_US
dc.identifier.issn2321-7219
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/242671
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber3en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.9734/ibrr/2024/v15i3341en_US
dc.subjectAntithrombinen_US
dc.subjectActivated partial thromboplastin timeen_US
dc.subjectprothrombin timeen_US
dc.subjectIschaemic strokeen_US
dc.titleAn Investigative Study of Prothrombin Time, Activated Partial Thromboplastin Time and Antithrombin Levels in Patients with Ischaemic Strokeen_US
dc.typeJournal Articleen_US
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