Efficacy of nimesulide alone and in combination with cetirizine in acute allergic rhinitis.

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dc.contributor.authorKotwani, Aen_US
dc.contributor.authorPuri, Ren_US
dc.contributor.authorGupta, Uen_US
dc.date.accessioned2001-05-22en_US
dc.date.accessioned2009-05-31T02:18:12Z
dc.date.available2001-05-22en_US
dc.date.available2009-05-31T02:18:12Z
dc.date.issued2001-05-22en_US
dc.description.abstractOBJECTIVE: To study the effect of cetirizine and nimesulide given alone and in combination in allergic rhinitis. METHOD: A double blind, double dummy, randomised, parallel controlled clinical study in three groups consisting of 18 patients each suffering from allergic rhinitis was conducted. Group A was given nimesulide alone (100 mg BD), Group B received combination (nimesulide 100 mg + cetirizine 10 mg) and Group C was given cetirizine alone (10 mg) for one week. The efficacy of each treatment in reducing nasal stuffiness, nasal discharge, itching nose and watery eyes was assessed at base line (day 0), on days four and eight of treatment. Patients used diary cards twice daily to rate symptom severity on a four point scale. RESULTS: Nimesulide and cetirizine alone could decrease nasal discharge, nasal stuffiness and sneezing significantly in allergic rhinitis patients by day four. Cetirizine was more effective in relieving nasal discharge and sneezing compared to nimesulide. By combining cetirizine and nimesulide four symptoms of allergic rhinitis, i.e., nasal discharge, nasal stuffiness, sneezing and watery eyes decreased significantly. CONCLUSION: Present study has shown that nimesulide alone could decrease three symptoms of allergic rhinitis like certirizine and combination of cetirizine (anti-histaminic) and nimesulide (anti-inflammatory) exerts synergistic action in reducing symptoms in patients of allergic rhinitis.en_US
dc.description.affiliationDepartment of Pharmacology, Maulana Azad Medical College and Associated LN Hospital, New Delhi.en_US
dc.identifier.citationKotwani A, Puri R, Gupta U. Efficacy of nimesulide alone and in combination with cetirizine in acute allergic rhinitis. Journal of the Association of Physicians of India. 2001 May; 49(): 518-22en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/92924
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal --administration & dosageen_US
dc.subject.meshCetirizine --administration & dosageen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRhinitis, Allergic, Seasonal --drug therapyen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshSulfonamides --administration & dosageen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleEfficacy of nimesulide alone and in combination with cetirizine in acute allergic rhinitis.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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