Association between lower hair zinc levels and neural tube defects.

Simple item page
dc.contributor.authorSrinivas, Men_US
dc.contributor.authorGupta, D Ken_US
dc.contributor.authorRathi, S Sen_US
dc.contributor.authorGrover, J Ken_US
dc.contributor.authorVats, Ven_US
dc.contributor.authorSharma, J Den_US
dc.contributor.authorMitra, D Ken_US
dc.date.accessioned2001-06-14en_US
dc.date.accessioned2009-05-30T12:34:03Z
dc.date.available2001-06-14en_US
dc.date.available2009-05-30T12:34:03Z
dc.date.issued2001-06-14en_US
dc.description.abstractThough folic acid supplementation has reduced the incidence of Neural Tube Defects (NTD), NTD still constitutes one of the important congenital malformations having wide medical, social and ethical implications. Zinc deficiency has been reported to produce NTD in animals. This study was designed to evaluate zinc status of the newborn babies with NTD and their mothers. Eighty newborn babies with NTD and their mothers served as cases. Eighty apparently normal newborn babies and their mothers served as controls. Serum and scalp hair zinc levels were analyzed by atomic absorption spectrophotometry. The mean (+/- SD) serum and hair levels in normal mothers were 74.1 +/- 4.1 micrograms/dl and 142.3 +/- 8.0 micrograms/g respectively. The mean (+/- SD) serum and hair levels of the mothers who delivered NTD babies were 75.7 +/- 5.6 micrograms/dl and 129.9 +/- 5.3 micrograms/g respectively. The mean (+/- SD) serum and hair levels in normal newborn babies were 77.8 +/- 5.3 micrograms/dl and 188.8 +/- 6.2 micrograms/g respectively. The mean (+/- SD) serum and hair levels in NTD babies were 80.1 +/- 12.9 micrograms/dl and 174.2 +/- 10.7 micrograms/g respectively. The hair zinc levels of the affected babies and their mothers were significantly lower (P < 0.001) than the controls. This study has found association between NTD and decreased hair zinc levels and large population based studies are recommended to confirm the association between zinc and NTD and to investigate whether zinc supplementation would reduce the overall incidence of NTD.en_US
dc.description.affiliationDepartment of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi-110029, India.en_US
dc.identifier.citationSrinivas M, Gupta DK, Rathi SS, Grover JK, Vats V, Sharma JD, Mitra DK. Association between lower hair zinc levels and neural tube defects. Indian Journal of Pediatrics. 2001 Jun; 68(6): 519-22en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/80815
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshDeveloping Countriesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHair --chemistryen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMeningocele --etiologyen_US
dc.subject.meshMeningomyelocele --etiologyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshZinc --analysisen_US
dc.titleAssociation between lower hair zinc levels and neural tube defects.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Pediatrics