Effect of glutamic acid and ketamine on morphine-induced analgesic response in rats.

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dc.contributor.authorSuman, Pen_US
dc.contributor.authorTalwar, Aen_US
dc.contributor.authorTandon, O Pen_US
dc.date.accessioned2000-01-05en_US
dc.date.accessioned2009-06-01T05:50:21Z
dc.date.available2000-01-05en_US
dc.date.available2009-06-01T05:50:21Z
dc.date.issued2000-01-05en_US
dc.description.abstractRats were treated with intraperitoneal injections of morphine (10 mg/kg) followed by glutamic acid (20 mg/kg.) and ketamine. (5 mg/kg). Pain thresholds were recorded as tail flick latencies for a period of 23 days and the mean area under curves calculated. Glutamic acid and ketamine, partially blocked the analgesic effects of morphine. Two types of effects were observed. In 4 animals, there was a partial blockade of the response, and in 2 animals there was a complete blockade followed by reversal in both the groups. It is suggested that two different mechanisms one excitatory and one inhibitory may be operating for the interaction of NMDA receptors with the opioid analgesic systems for modulating nociceptive responses.en_US
dc.description.affiliationDepartment of Physiology, University College of Medical Sciences, Shahadara, Delhi.en_US
dc.identifier.citationSuman P, Talwar A, Tandon OP. Effect of glutamic acid and ketamine on morphine-induced analgesic response in rats. Indian Journal of Physiology and Pharmacology. 2000 Jan; 44(1): 33-42en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106922
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnalgesics, Opioid --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArea Under Curveen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshExcitatory Amino Acid Antagonists --pharmacologyen_US
dc.subject.meshGlutamic Acid --pharmacologyen_US
dc.subject.meshKetamine --pharmacologyen_US
dc.subject.meshMicroinjectionsen_US
dc.subject.meshMorphine --pharmacologyen_US
dc.subject.meshPain Measurement --drug effectsen_US
dc.subject.meshPain Threshold --drug effectsen_US
dc.subject.meshPeripheral Nervous System --drug effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshReaction Time --drug effectsen_US
dc.titleEffect of glutamic acid and ketamine on morphine-induced analgesic response in rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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