Carbamazepine-induced hypersensitivity pneumonitis in a patient with neuromyelitis optica: A case report

dc.contributor.authorKhan, Furqan Mohd. Akramen_US
dc.contributor.authorDave, Dhavalen_US
dc.contributor.authorRohatgi, Shaleshen_US
dc.contributor.authorNirhale, Satishen_US
dc.contributor.authorRao, Prajwalen_US
dc.contributor.authorNaphade, Pravinen_US
dc.contributor.authorKotaru, V. V. Sravyaen_US
dc.contributor.authorGupta, Sahilen_US
dc.contributor.authorGupta, Advaiten_US
dc.contributor.authorDubey, Prashanten_US
dc.date.accessioned2023-08-19T04:57:24Z
dc.date.available2023-08-19T04:57:24Z
dc.date.issued2022-03
dc.description.abstractA 36-year-old female with serum anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (NMOSD) on carbamazepine (CBZ) therapy for paroxysmal tonic spasms (PTS) developed Type 1 respiratory failure. High-resolution computed tomography chest showed diffuse ground-glass opacities in both lungs predominantly in bilateral perihilar region sparing subpleural regions and predominantly upper lobes with a smooth interlobular septal thickening. A transbronchial lung biopsy was consistent with hypersensitivity pneumonitis and following withdrawal of the CBZ and treatment with steroids her respiratory symptoms resolved. After stopping CBZ, PTS recurred, which was successfully treated with lacosamide. This is the first described biopsy-proven case of CBZ-induced hypersensitivity pneumonitis in the NMOSD patient.en_US
dc.identifier.affiliationsDepartment of Neurology, Dr. D. Y. Patil Vidyapeeth, Pune; D. Y. Patil Medical College, Hospital & Research Centre, Pune, Maharashtra, Indiaen_US
dc.identifier.citationKhan Furqan Mohd. Akram, Dave Dhaval, Rohatgi Shalesh, Nirhale Satish, Rao Prajwal, Naphade Pravin, Kotaru V. V. Sravya, Gupta Sahil, Gupta Advait, Dubey Prashant. Carbamazepine-induced hypersensitivity pneumonitis in a patient with neuromyelitis optica: A case report. Indian Journal of Physiology and Pharmacology. 2022 Mar; 66(1): 81-83en_US
dc.identifier.issn0019-5499
dc.identifier.issn2582-2799
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223995
dc.languageenen_US
dc.publisherScientific Scholar on behalf of Association of Physiologists and Pharmacologists of Indiaen_US
dc.relation.issuenumber1en_US
dc.relation.volume66en_US
dc.source.urihttps://doi.org/10.25259/IJPP_282_2021en_US
dc.subjectNeuromyelitis optica spectrum disorderen_US
dc.subjectParoxysmal tonic spasmsen_US
dc.subjectCarbamazepineen_US
dc.subjectHypersensitivity pneumonitisen_US
dc.subjectLacosamideen_US
dc.titleCarbamazepine-induced hypersensitivity pneumonitis in a patient with neuromyelitis optica: A case reporten_US
dc.typeJournal Articleen_US
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