Studies of immune response to hepatitis B vaccine in Thai blood donors.

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dc.contributor.authorNuchprayoon, Cen_US
dc.contributor.authorO-Charoen, R Oen_US
dc.contributor.authorVaivanijkul, Jen_US
dc.contributor.authorApirakyothin, Ten_US
dc.contributor.authorAkkawat, Ren_US
dc.contributor.authorChumnijarakij, Ten_US
dc.date.accessioned2009-05-27T16:57:14Z
dc.date.available2009-05-27T16:57:14Z
dc.date.issued1992-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe immunogenicity of heat-inactivated plasma derived hepatitis B vaccines were studied in one hundred and eighty-two adult blood donor volunteers whose HBV markers (HBsAg, anti-HBs) were negative. They were randomized for four regimens of 3 micrograms intramuscular Hepaccine-B vaccine at the schedules of 0, 1, 2, 9 months, 0, 1, 3, 9 months, 0, 2, 6, 12 months, 0, 1, 6, 12 months and another regimen of 5 micrograms Hevac-B Pasteur vaccine at 0, 1, 2, 9 months. Blood specimens, tested for serological marker (anti-HBs), were drawn at 1, 3, 6, 9, 12 and 15 months following the initial injection. The outcome revealed that the Hepaccine-B vaccinated group in the schedules of 0, 2, 6, 12 and 0, 1, 6, 12 months yielded seroconversion rates of 48.7% and 56.8%, respectively one month after vaccination. After that, the immune response (anti-HBs titer) regularly increased every three months until it reached 100% with a geometric mean (GMT) of 135 and 130 mIU/ml respectively in the fifteenth month. Taking the Hepaccine-B and the Hevac-B Pasteur with the same schedule (0, 1, 2, 9 months) into consideration, we found that the former yielded the higher seroconversion rate, one month after the initial injection, which increased to the highest rate of 95.8% in the ninth month. After that it was steady until the fifteenth month with higher GMT (584 mIU/ml) than that of Hevac-B Pasteur (323 mIU/ml). The seroconversion rate of Hevac-B Pasteur in the first month was lower than that of Hepaccine-B but it yielded the highest rate of 100% in the sixth month. After that, it gradually decreased and again increased to 100% in the fifteenth month.en_US
dc.description.affiliationNational Blood Center, Thai Red Cross Society, Bangkok.en_US
dc.identifier.citationNuchprayoon C, O-Charoen RO, Vaivanijkul J, Apirakyothin T, Akkawat R, Chumnijarakij T. Studies of immune response to hepatitis B vaccine in Thai blood donors. The Southeast Asian Journal of Tropical Medicine and Public Health. 1992 Mar; 23(1): 17-21en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36385
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAntibody Formation --immunologyen_US
dc.subject.meshBlood Donorsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B Antibodies --blooden_US
dc.subject.meshHepatitis B Vaccinesen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunization Scheduleen_US
dc.subject.meshInjections, Intramuscularen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshThailanden_US
dc.subject.meshViral Hepatitis Vaccines --administration & dosageen_US
dc.titleStudies of immune response to hepatitis B vaccine in Thai blood donors.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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