Halofantrine in the treatment of acute uncomplicated falciparum malaria in the Philippines.

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dc.contributor.authorSalazar, N Pen_US
dc.contributor.authorCarlos, C Cen_US
dc.contributor.authorBustos, D Gen_US
dc.contributor.authorQuiambao, B Pen_US
dc.contributor.authorSaniel, M Cen_US
dc.contributor.authorSantos, M Nen_US
dc.date.accessioned2009-05-27T15:43:00Z
dc.date.available2009-05-27T15:43:00Z
dc.date.issued1991-09-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractIn an open clinical trial, thirty patients 14 to 44 years old and with acute uncomplicated falciparum malaria were given halofantrine hydrochloride 500 mg (2 tablets) 6-hourly for 3 doses, a total dose of 1500 mg. All 30 patients were cured, with a mean asexual parasite clearance time of 47.6 hours and mean fever clearance time of 36.6 hours. Post-dosing side-effects occurred in 6 patients consisting of mild to moderate headache, dizziness and abdominal muscle spasm. Drug-induced hemolysis did not occur in two G6PD deficient patients. Twenty-three out of 28 isolates tested (82%) were resistant to amodiaquine, 3 (11%) were resistant to the sulfadoxine-pyrimethamine combination, and all were sensitive to chloroquine, quinine and mefloquine by in vitro microtests. The study confirms the efficacy of halofantrine hydrochloride as a blood schizonticide in falciparum malaria.en_US
dc.description.affiliationResearch Institute for Tropical Medicine, Department of Health, Alabang, Muntinlupa, Metro Manila, Philippines.en_US
dc.identifier.citationSalazar NP, Carlos CC, Bustos DG, Quiambao BP, Saniel MC, Santos MN. Halofantrine in the treatment of acute uncomplicated falciparum malaria in the Philippines. The Southeast Asian Journal of Tropical Medicine and Public Health. 1991 Sep; 22(3): 386-92en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/33484
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBlood Cell Counten_US
dc.subject.meshBlood Chemical Analysisen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshHematocriten_US
dc.subject.meshHemoglobins --analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshMalaria, Falciparum --blooden_US
dc.subject.meshParasite Egg Counten_US
dc.subject.meshPhenanthrenes --administration & dosageen_US
dc.titleHalofantrine in the treatment of acute uncomplicated falciparum malaria in the Philippines.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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