Double blind clinical trial on centperazine & DEC in bancroftian filariasis.

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dc.contributor.authorRath, R Nen_US
dc.contributor.authorDas, B Ken_US
dc.contributor.authorAli, M Len_US
dc.contributor.authorDas, P Ken_US
dc.contributor.authorMishra, A Cen_US
dc.contributor.authorMohapatra, B Nen_US
dc.date.accessioned1990-07-01en_US
dc.date.accessioned2009-05-27T07:14:10Z
dc.date.available1990-07-01en_US
dc.date.available2009-05-27T07:14:10Z
dc.date.issued1990-07-01en_US
dc.description.abstractCentperazine, an analogue of DEC, was subjected to a double blind controlled trial, to evaluate its efficacy as a newer antifilarial agent. Centperazine (300 mg/day) along with equivalent quantities of DEC and placebo were administered to different types of filariasis patients. DEC was found to be significantly effective in reducing peripheral microfilaraemia, in different weeks and months of follow-up, except at the end of 6th month, as compared to Centperazine. There was no significant difference between the placebo and Centperazine treated patients, in this respect, revealing that the drugs had no efficacy in eliminating peripheral microfilaraemia. Recurrence of acute attack within 6 months was nearly equal with both Centperazine and DEC, being 28.2 and 24 per cent respectively, whereas in the placebo group the recurrence rate was 48.9 per cent. Centperazine treated patients showed significantly less side effects (8.9%), as compared to DEC treated patients (34%). Giddiness, nausea and vomiting were the common adverse effects observed.en_US
dc.description.affiliationDepartment of Medicine, S.C.B. Medical College.en_US
dc.identifier.citationRath RN, Das BK, Ali ML, Das PK, Mishra AC, Mohapatra BN. Double blind clinical trial on centperazine & DEC in bancroftian filariasis. Indian Journal of Medical Research. 1990 Jul; 91(): 277-81en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/19866
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnimalsen_US
dc.subject.meshDiethylcarbamazine --therapeutic useen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshElephantiasis, Filarial --drug therapyen_US
dc.subject.meshFilaricides --therapeutic useen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPiperazines --therapeutic useen_US
dc.subject.meshWuchereria bancrofti --drug effectsen_US
dc.titleDouble blind clinical trial on centperazine & DEC in bancroftian filariasis.en_US
dc.typeClinical Trialen_US
dc.typeControlled Clinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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