Effects of medial septal stimulation & its blockade with atropine on hippocampal rhythmical slow activity in free-moving rabbits.

Simple item page
dc.contributor.authorDhume, R Aen_US
dc.contributor.authorShamayev, N Nen_US
dc.contributor.authorZhuravlev, B Ven_US
dc.contributor.authorSudakov, K Ven_US
dc.contributor.authorSharma, K Nen_US
dc.date.accessioned1990-10-01en_US
dc.date.accessioned2009-05-27T08:21:42Z
dc.date.available1990-10-01en_US
dc.date.available2009-05-27T08:21:42Z
dc.date.issued1990-10-01en_US
dc.description.abstractThe influence of the medial septal nucleus (MSN) on hippocampal rhythmical slow activity (RSA) was investigated in hunger motivated free-moving rabbits. Single unit activity of 29 CA3 dorsal hippocampal neurones was studied under two paradigms viz., electrical stimulation (3v/1msec/5Hz) and chemical blockade of atropine-sensitive medial septal cells (dose of 5 micrograms in 5 microliters). The analysis of interspike interval sample histograms recorded with Apple II, along with single unit neuronal spikes recorded on polygraph showed bimodal pattern with two peaks; one at bin 10-20 (high frequency) and second at bin 100-300 (theta frequency). On stimulation of MSN, there was total suppression of bin 100-300 with peaks at bin 1-20 and at bin greater than 1000 (very low frequency). Blockade of cholinergic receptors at MSN showed reduction of bin 100-300 and peak at bin 700- greater than 1000; this was followed by gradual decrease of spike's amplitude and thereafter its total abolition. The results indicate that the septal region is not a pacemaker per se in the genesis of hippocampal RSA (theta rhythm), but serves more in the nature of a relay station for a number of inputs and that its influence on the hippocampal electrical activity depends on the integrity of cholinergic inputs, be it from hippocampus proper or from mid-brain reticular formation.en_US
dc.description.affiliationAnokhin Institute of Normal Physiology, USSR Academy of Medical Sciences, Moscow.en_US
dc.identifier.citationDhume RA, Shamayev NN, Zhuravlev BV, Sudakov KV, Sharma KN. Effects of medial septal stimulation & its blockade with atropine on hippocampal rhythmical slow activity in free-moving rabbits. Indian Journal of Medical Research. 1990 Oct; 92(): 353-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/24177
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAtropine --pharmacologyen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshHippocampus --cytologyen_US
dc.subject.meshHunger --physiologyen_US
dc.subject.meshMotor Activityen_US
dc.subject.meshNeurons --physiologyen_US
dc.subject.meshPeriodicityen_US
dc.subject.meshRabbitsen_US
dc.subject.meshSeptal Nuclei --physiologyen_US
dc.titleEffects of medial septal stimulation & its blockade with atropine on hippocampal rhythmical slow activity in free-moving rabbits.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Medical Research