A study on pre-XDR & XDR tuberculosis & their prevalent genotypes in clinical isolates of Mycobacterium tuberculosis in north India.

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dc.contributor.authorSinghal, Parul
dc.contributor.authorDixit, Pratima
dc.contributor.authorSingh, Pooja
dc.contributor.authorJaiswal, Indu
dc.contributor.authorSingh, Mastan
dc.contributor.authorJain, Amita
dc.date.accessioned2016-08-05T11:15:57Z
dc.date.available2016-08-05T11:15:57Z
dc.date.issued2016-03
dc.description.abstractBackground & objectives: Pre-extensively drug resistant (pre-XDR) and extensively drug resistant tuberculosis (XDR-TB) have been areas of growing concern, and are posing threat to global efforts of TB control. The present study was planned to study the presence of pre-XDR and XDR Mycobacterium tuberculosis and their genotypes in clinical isolates obtained from previously treated cases of pulmonary TB. Methods: A total of 219 isolates obtained from previously treated cases of pulmonary TB were subjected to first-line (streptomycin, isoniazid, rifampicin and ethambutol) and second-line (ofloxacin, kanamycin, capreomycin and amikacin) drug susceptibility testing on solid Lowenstein-Jensen medium by proportion method. Genotyping was done for pre-XDR and XDR-TB isolates using 12 loci Mycobacterial Interspersed Repetitive Units-Variable Number Tandem Repeats (MIRU-VNTR). Results: Multi-drug resistance was observed in 39.7 per cent (87/219) isolates. Pre-XDR and XDR M. tuberculosis isolates amongst 87 multi-drug resistant (MDR) TB isolates were 43 (49.4%) and 10 (11.4%), respectively. Two most dominant genotypes among pre-XDR and XDR M. tuberculosis isolates were Beijing and Delhi/CAS types. Interpretation & conclusions: Resistance to second-line anti-tubercular drugs should be routinely assessed in areas endemic for TB. Similar genotype patterns were seen in pre-XDR and XDR-TB isolates. Beijing and Delhi/CAS were predominant genotypes.en_US
dc.identifier.citationSinghal Parul, Dixit Pratima, Singh Pooja, Jaiswal Indu, Singh Mastan, Jain Amita. A study on pre-XDR & XDR tuberculosis & their prevalent genotypes in clinical isolates of Mycobacterium tuberculosis in north India. Indian Journal of Medical Research. 2016 Mar; 143(3): 341-347.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/176460
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892081/en_US
dc.subjectMDR-TBen_US
dc.subjectMIRU-VNTRen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectpre-XDR-TBen_US
dc.subjectXDR-TBen_US
dc.titleA study on pre-XDR & XDR tuberculosis & their prevalent genotypes in clinical isolates of Mycobacterium tuberculosis in north India.en_US
dc.typeArticleen_US
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