Clinical and Immunological Profile of Systemic Lupus Erythematosus.
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Date
2013-04
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Abstract
Pediatric onset systemic lupus erythematosus (SLE) is not uncommon and female to male
ratio varies. Pediatric SLE patients have more severe disease at onset, higher rates of organ
involvement and more aggressive clinical course than adults. We compared the clinical and
immunological parameters among pediatric SLE and adult SLE from Western India. Twenty
five children and 60 adult patients fulfilling American College of Rheumatology SLE criteria
were included. Anti-nuclear antibodies, anti-dsDNA and complement (C3, C4) levels were
tested. Of 25 pediatric SLE patients studied, 24% showed CNS involvement vs. 8.3% in
adults SLE (P=0.0499). Lupus nephritis was seen in 75% adult patients vs. 52% among
children. Hepatosplenomegaly was noted more among adult SLE 26.8% vs 12% among
children. Alopecia was an exclusive features among adult SLE.
Description
Keywords
Autoantibodies, Child, Lupus nephritis, India, Systemic lupus erythematosus
Citation
Pradhan V, Patwardhan M, Rajadhyaksha A, Ghosh K. Clinical and Immunological Profile of Systemic Lupus Erythematosus. Indian Pediatrics. 2013 April; 50(4): 405-407.